Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2006616..2007255 Replicon chromosome
Accession NZ_CP023504
Organism Citrobacter werkmanii strain FDAARGOS_364

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CO701_RS10005 Protein ID WP_096756975.1
Coordinates 2006616..2006792 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CO701_RS10010 Protein ID WP_137398867.1
Coordinates 2006839..2007255 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO701_RS09985 2003397..2003627 - 231 WP_096756971.1 DUF2554 family protein -
CO701_RS09990 2003814..2003939 - 126 WP_096756972.1 DUF2474 domain-containing protein -
CO701_RS09995 2003939..2004949 - 1011 WP_096756973.1 cytochrome d ubiquinol oxidase subunit II -
CO701_RS10000 2004949..2006352 - 1404 WP_096756974.1 cytochrome ubiquinol oxidase subunit I -
CO701_RS10005 2006616..2006792 + 177 WP_096756975.1 type II toxin-antitoxin system HicA family toxin Toxin
CO701_RS10010 2006839..2007255 + 417 WP_137398867.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CO701_RS10015 2007349..2008758 + 1410 WP_096756977.1 PLP-dependent aminotransferase family protein -
CO701_RS10020 2009089..2010234 + 1146 WP_096756978.1 ABC transporter substrate-binding protein -
CO701_RS10025 2010251..2011267 + 1017 WP_096756979.1 ABC transporter ATP-binding protein -
CO701_RS10030 2011268..2012212 + 945 WP_096756980.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-68)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6737.76 Da        Isoelectric Point: 11.2510

>T81422 WP_096756975.1 NZ_CP023504:2006616-2006792 [Citrobacter werkmanii]
VKQSEFRRWLESQGVDITHGSNHVKLRYQGRRSVMPRHPGDEIKEALRKAILKQLGLS

Download         Length: 177 bp

>T81422 NZ_CP023504:2006616-2006792 [Citrobacter werkmanii]
GTGAAGCAAAGCGAGTTCAGGCGCTGGCTTGAATCTCAGGGAGTTGATATCACTCATGGCTCGAATCATGTGAAGCTGAG
GTATCAGGGAAGGCGCAGCGTTATGCCCAGACATCCTGGTGATGAGATAAAAGAAGCCTTGCGAAAAGCAATTCTTAAGC
AGCTGGGTTTATCGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15171.31 Da        Isoelectric Point: 4.4938

>AT81422 WP_137398867.1 NZ_CP023504:2006839-2007255 [Citrobacter werkmanii]
MRYPVNLKPAVEGGFVVSFPDIPEALTQGDSRHEALEAAQDALVTAFEFYFDDNETIPLPSAVDAADDYVEIPLSVASKV
LLLNTFLEAKITQQELASRIGRPKQEITRLFDLKHATKIDAVQAAVRALGKQLSLTMQ

Download         Length: 417 bp

>AT81422 NZ_CP023504:2006839-2007255 [Citrobacter werkmanii]
ATGCGCTATCCCGTCAATCTAAAGCCCGCCGTAGAAGGTGGGTTTGTGGTCTCTTTCCCGGATATTCCAGAAGCATTAAC
GCAGGGGGATTCTCGCCATGAAGCCCTGGAGGCGGCGCAGGATGCACTGGTTACCGCTTTCGAATTTTATTTCGACGATA
ACGAGACTATTCCTTTGCCTTCGGCGGTTGATGCGGCTGATGATTATGTCGAAATCCCCCTGAGCGTTGCTTCTAAGGTG
CTTCTGCTAAATACCTTCCTGGAAGCAAAAATCACCCAACAGGAGTTGGCGAGTCGGATTGGCAGACCTAAGCAGGAAAT
CACCCGGCTATTCGATTTAAAGCATGCGACCAAAATCGATGCCGTGCAGGCTGCGGTGCGAGCATTAGGTAAACAGCTTT
CGTTAACGATGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References