Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 353949..354752 Replicon chromosome
Accession NZ_CP023504
Organism Citrobacter werkmanii strain FDAARGOS_364

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag CO701_RS01765 Protein ID WP_024156451.1
Coordinates 353949..354329 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5A9BSL8
Locus tag CO701_RS01770 Protein ID WP_038807908.1
Coordinates 354387..354752 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO701_RS01730 349378..350286 - 909 WP_096755714.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CO701_RS01735 350276..350815 - 540 WP_096755715.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
CO701_RS01745 351414..351793 - 380 Protein_324 DUF4102 domain-containing protein -
CO701_RS01750 352305..353152 - 848 Protein_325 DUF4942 domain-containing protein -
CO701_RS01760 353461..353952 - 492 WP_024156452.1 hypothetical protein -
CO701_RS01765 353949..354329 - 381 WP_024156451.1 TA system toxin CbtA family protein Toxin
CO701_RS01770 354387..354752 - 366 WP_038807908.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CO701_RS01775 354774..354995 - 222 WP_024156449.1 DUF987 domain-containing protein -
CO701_RS01780 355009..355488 - 480 WP_024156448.1 DNA repair protein RadC -
CO701_RS01785 355501..355974 - 474 WP_024156447.1 antirestriction protein -
CO701_RS01795 356243..357061 - 819 WP_048242033.1 DUF945 domain-containing protein -
CO701_RS01800 357177..357437 - 261 WP_048242035.1 DUF905 family protein -
CO701_RS01805 357628..358095 - 468 WP_048242036.1 hypothetical protein -
CO701_RS01810 358192..358593 - 402 WP_048242038.1 hypothetical protein -
CO701_RS01815 358799..359686 - 888 WP_048242072.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T81411 WP_024156451.1 NZ_CP023504:c354329-353949 [Citrobacter werkmanii]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T81411 NZ_CP023504:c354329-353949 [Citrobacter werkmanii]
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13344.20 Da        Isoelectric Point: 5.8705

>AT81411 WP_038807908.1 NZ_CP023504:c354752-354387 [Citrobacter werkmanii]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp

>AT81411 NZ_CP023504:c354752-354387 [Citrobacter werkmanii]
TTGTCGAATCCAATACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGTTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGGGCCAGTATCGCCGGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAAGCATTTCCGGTACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCTGCCATCAGCACTGTGTCACGTTATATGCAAAAGGGCTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JYU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BSL8

References