Detailed information of TA system TA081395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 585209..585741
• Replicon: chromosome
• Accession: NZ_CP023500
• Organism: Staphylococcus aureus strain FDAARGOS_412

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: CO684_RS03140
• Protein ID: WP_001103942.1
• Coordinates: 585421..585741 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: CO684_RS03135
• Protein ID: WP_001058486.1
• Coordinates: 585209..585418 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO684_RS03090	580228..581448	-	1221	WP_000266157.1	site-specific integrase	-
CO684_RS03095	581537..582265	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
CO684_RS03100	582289..583017	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
CO684_RS03105	583087..583518	-	432	WP_001228759.1	hypothetical protein	-
CO684_RS03110	583535..583993	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
CO684_RS03115	584005..584337	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
CO684_RS03120	584530..584793	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
CO684_RS03125	584786..585058	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
CO684_RS03130	585070..585216	+	147	WP_000784875.1	hypothetical protein	-
CO684_RS03135	585209..585418	+	210	WP_001058486.1	hypothetical protein	Antitoxin
CO684_RS03140	585421..585741	+	321	WP_001103942.1	DUF1474 family protein	Toxin
CO684_RS03145	585805..586674	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
CO684_RS03150	586691..588148	+	1458	WP_000390455.1	virulence-associated E family protein	-
CO684_RS03155	588449..588811	+	363	WP_001039168.1	hypothetical protein	-
CO684_RS03160	588813..589097	+	285	WP_000998181.1	hypothetical protein	-
CO684_RS03165	589094..589735	+	642	WP_001019764.1	hypothetical protein	-
CO684_RS03170	590252..590593	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	564447..595543	31096

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T81395 WP_001103942.1 NZ_CP023500:585421-585741 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T81395 NZ_CP023500:585421-585741 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT81395 WP_001058486.1 NZ_CP023500:585209-585418 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT81395 NZ_CP023500:585209-585418 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4