Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 567595..568072 Replicon chromosome
Accession NZ_CP023500
Organism Staphylococcus aureus strain FDAARGOS_412

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag CO684_RS02990 Protein ID WP_000052077.1
Coordinates 567595..567783 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CO684_RS02995 Protein ID WP_001059690.1
Coordinates 567812..568072 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO684_RS02960 563636..564106 + 471 WP_000824472.1 hypothetical protein -
CO684_RS02965 564447..565133 + 687 WP_001548082.1 thermonuclease family protein -
CO684_RS02970 565490..565690 + 201 WP_001059082.1 cold-shock protein -
CO684_RS02975 566186..566404 - 219 WP_000005886.1 hypothetical protein -
CO684_RS02980 566466..566750 - 285 WP_001004395.1 hypothetical protein -
CO684_RS02985 566838..567407 - 570 WP_001106654.1 hypothetical protein -
CO684_RS02990 567595..567783 - 189 WP_000052077.1 hypothetical protein Toxin
CO684_RS02995 567812..568072 - 261 WP_001059690.1 hypothetical protein Antitoxin
CO684_RS03000 568413..568616 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CO684_RS03005 568613..568849 - 237 WP_000368687.1 hypothetical protein -
CO684_RS03010 569074..569655 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CO684_RS03015 569728..570345 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CO684_RS03020 570500..570994 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CO684_RS03025 571393..571815 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CO684_RS03030 571963..572679 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 564447..595543 31096


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T81394 WP_000052077.1 NZ_CP023500:c567783-567595 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T81394 NZ_CP023500:c567783-567595 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT81394 WP_001059690.1 NZ_CP023500:c568072-567812 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT81394 NZ_CP023500:c568072-567812 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References