Detailed information of TA system TA081392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2826446..2827139
• Replicon: chromosome
• Accession: NZ_CP023499
• Organism: Burkholderia thailandensis strain FDAARGOS_426

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A132EML3
• Locus tag: CO709_RS26655
• Protein ID: WP_015601891.1
• Coordinates: 2826762..2827139 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: CO709_RS26650
• Protein ID: WP_015600977.1
• Coordinates: 2826446..2826781 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO709_RS26630	2822562..2823110	+	549	WP_015600544.1	hypothetical protein	-
CO709_RS26635	2823094..2825466	+	2373	Protein_2593	DEAD/DEAH box helicase family protein	-
CO709_RS26640	2825576..2826256	+	681	WP_015601902.1	hypothetical protein	-
CO709_RS26645	2826294..2826449	-	156	Protein_2595	HigA family addiction module antidote protein	-
CO709_RS26650	2826446..2826781	-	336	WP_015600977.1	helix-turn-helix domain-containing protein	Antitoxin
CO709_RS26655	2826762..2827139	-	378	WP_015601891.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CO709_RS26660	2827551..2829020	+	1470	WP_015601175.1	aldehyde dehydrogenase family protein	-
CO709_RS26665	2829157..2829678	-	522	WP_015602266.1	DUF2867 domain-containing protein	-
CO709_RS26670	2829925..2830554	-	630	WP_015602117.1	TetR/AcrR family transcriptional regulator	-
CO709_RS26675	2831000..2832130	+	1131	WP_015601089.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2819587..2832130	12543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-97)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13718.79 Da
• Isoelectric Point: 8.8594

>T81392 WP_015601891.1 NZ_CP023499:c2827139-2826762 [Burkholderia thailandensis]
MADKEKPLEWIASSYKDLMALPPDVRRRFGYALSLAQMGDQDDAAKVLKGFGGAGVLEVVEDDTGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKGDMDIIRARLKVAEALAQELRNAKTNH

Nucleotide

• Length: 378 bp

>T81392 NZ_CP023499:c2827139-2826762 [Burkholderia thailandensis]
ATGGCCGACAAAGAAAAACCTCTCGAATGGATTGCGAGCAGCTACAAGGATCTGATGGCGTTGCCGCCCGATGTTCGCCG
GCGCTTCGGTTACGCGCTGTCGTTAGCGCAGATGGGCGACCAGGACGATGCGGCAAAGGTGCTCAAGGGCTTCGGCGGAG
CCGGCGTGCTAGAGGTCGTCGAGGATGATACCGGCGGCACGTACCGGGCCGTCTATACAGTCAAGTTCGCCGAGGCGGTG
TTCGTCCTGCACTGCTTCCAGAAAAAGAGCAAGAGTGGGATCGCCACGCCGAAAGGCGACATGGACATCATTCGCGCTCG
GTTGAAAGTGGCCGAAGCATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12152.36 Da
• Isoelectric Point: 10.2130

>AT81392 WP_015600977.1 NZ_CP023499:c2826781-2826446 [Burkholderia thailandensis]
MQKRIIEGVEVQRGSGNVYADLGLPDAEKLKIKTGLVIEIRKAMRALGLTQQAAAKRMGIPQPKVSGMMHGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLAVA

Nucleotide

• Length: 336 bp

>AT81392 NZ_CP023499:c2826781-2826446 [Burkholderia thailandensis]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCGGTTCGGGCAATGTCTATGCCGACCTCGGCTTGCCCGATGC
AGAAAAACTGAAGATCAAGACCGGCTTGGTAATCGAAATCAGAAAAGCCATGCGTGCCCTCGGACTCACTCAACAAGCCG
CGGCGAAACGCATGGGCATTCCGCAGCCGAAGGTGTCCGGCATGATGCATGGTGACTTCACTAACCTGTCCGAGCGCAAG
CTGATGGACTGCTTGAATCGGCTAGGCTACGACATCGAGATCAAGGTACGGCCGGCCGCCGAACCGATCGGGCATCTCAC
GCTCGCGGTCGCTTGA

Structures

Toxin

• AlphaFold DB: A0A132EML3