Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1280684..1282449 Replicon chromosome
Accession NZ_CP023498
Organism Burkholderia thailandensis strain FDAARGOS_426

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CO709_RS05580 Protein ID WP_015602947.1
Coordinates 1281535..1282449 (-) Length 305 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CO709_RS05575 Protein ID WP_015603863.1
Coordinates 1280684..1281538 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO709_RS05555 1275900..1277390 - 1491 WP_015603069.1 aldehyde dehydrogenase -
CO709_RS05560 1277416..1278231 - 816 WP_015603755.1 aspartate dehydrogenase -
CO709_RS05565 1278224..1279897 - 1674 WP_015604105.1 thiamine pyrophosphate-binding protein -
CO709_RS05570 1279890..1280687 - 798 WP_015602774.1 SDR family oxidoreductase -
CO709_RS05575 1280684..1281538 - 855 WP_015603863.1 IclR family transcriptional regulator Antitoxin
CO709_RS05580 1281535..1282449 - 915 WP_015602947.1 alpha/beta fold hydrolase Toxin
CO709_RS05585 1282466..1282993 - 528 WP_015603157.1 cupin domain-containing protein -
CO709_RS05590 1283032..1283802 - 771 WP_015603778.1 SDR family oxidoreductase -
CO709_RS05595 1283799..1284866 - 1068 WP_015603807.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CO709_RS05600 1284901..1285212 - 312 WP_006027427.1 hypothetical protein -
CO709_RS05605 1285214..1285531 - 318 WP_009914826.1 non-heme iron oxygenase ferredoxin subunit -
CO709_RS05615 1285967..1287055 + 1089 WP_009914825.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-287)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 31189.09 Da        Isoelectric Point: 7.1483

>T81391 WP_015602947.1 NZ_CP023498:c1282449-1281535 [Burkholderia thailandensis]
MSAISTTTAGASAMPFAALLERFAERHAAAGDAGTIGYREAGESYGERTEQAGRDPVVLLHGIGSGAASWVRQLDALGAT
RRALAWDAPGYGASSRVAAGSPVAADYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARIASERLAGLLLISPAGGYGG
TPADVRAERRDSRLALLASLGPQGLADERSANLLSAHASDTARAWVHWNMARIAPAGYAQATHLLANADLASDLVHYRGR
VAVAVGGDDAITPPAACERIARAARVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAT

Download         Length: 915 bp

>T81391 NZ_CP023498:c1282449-1281535 [Burkholderia thailandensis]
ATGAGCGCGATTTCCACGACGACAGCCGGCGCGAGCGCGATGCCTTTCGCCGCGCTGCTCGAACGCTTCGCCGAGCGACA
CGCGGCGGCGGGCGACGCGGGCACGATCGGCTACCGCGAGGCGGGCGAATCGTACGGCGAGCGCACTGAGCAAGCCGGGC
GCGATCCCGTCGTGCTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCGACG
CGTCGCGCGCTCGCGTGGGACGCGCCAGGCTATGGCGCATCGTCACGCGTCGCGGCCGGCTCGCCCGTCGCGGCCGACTA
CGCGGCGTCGCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCG
TCGCCGGCGCGTTCGCGCGGATCGCGAGCGAGCGGCTTGCGGGATTGCTGCTGATTTCTCCTGCCGGCGGCTACGGCGGC
ACGCCCGCCGACGTGCGGGCCGAGCGGCGCGACAGCCGTCTCGCACTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGA
CGAGCGCAGCGCAAACCTGTTGTCCGCGCATGCGAGCGACACGGCGCGCGCGTGGGTGCACTGGAACATGGCGCGCATCG
CGCCCGCCGGCTATGCGCAGGCGACGCATCTGCTCGCGAACGCGGATCTCGCGTCCGATCTCGTCCATTACCGCGGCCGC
GTCGCGGTCGCCGTCGGCGGCGACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATTGCGCGCGCGGCGCGTGTTGG
GCTGCAGGTGATTCCCCGTGCGGGCCATGCCGGCTACGTTGAAGCGCCCGATGCGTACAGTGCGTTGATCGACGCTTTTT
GCCGTCAATGCGACGGATCGCGAGGCGCGACATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31015.47 Da        Isoelectric Point: 7.4665

>AT81391 WP_015603863.1 NZ_CP023498:c1281538-1280684 [Burkholderia thailandensis]
MSEPLLKDADNAKNDSNYVVPGLERGLRVLAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVADGLIEKVVRAAGGLSRRLNYRADDENTYLKALGLR

Download         Length: 855 bp

>AT81391 NZ_CP023498:c1281538-1280684 [Burkholderia thailandensis]
ATGAGCGAACCGCTGCTGAAGGACGCCGACAACGCGAAGAATGATTCGAACTACGTAGTACCGGGGCTCGAGCGCGGGCT
GCGGGTCCTGGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAGTCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGCCTC
GGCGTCGCGGTGTTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACTGATCTCGGCTTGCCGGTGATAGAAGG
CTTGCGCGATGCGACGGGCTTCACGGCGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCCGAGTTGCGCGCGCTGTATCCGGAGCGGGAGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACTGTCGACGCGCTCTTCGACGTGATTCGCGCCGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGACGGGCTGATCGAGAAGGTCGTGCGCGCGGCGGGCGGACTGTCGCGGCGGCT
CAACTACCGGGCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References