Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 280965..281479 Replicon chromosome
Accession NZ_CP023497
Organism Staphylococcus simulans strain FDAARGOS_383

Toxin (Protein)


Gene name TsdT Uniprot ID A0A133QQ97
Locus tag CO689_RS02350 Protein ID WP_002481764.1
Coordinates 280965..281171 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A133QQA1
Locus tag CO689_RS02355 Protein ID WP_002481765.1
Coordinates 281186..281479 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO689_RS02330 276813..278129 + 1317 WP_057510927.1 ISL3 family transposase -
CO689_RS14120 278233..278373 - 141 WP_023016106.1 hypothetical protein -
CO689_RS02340 278455..280647 - 2193 WP_096754319.1 heavy metal translocating P-type ATPase -
CO689_RS02345 280740..280946 - 207 WP_002481763.1 copper ion binding protein -
CO689_RS02350 280965..281171 - 207 WP_002481764.1 heavy-metal-associated domain-containing protein Toxin
CO689_RS02355 281186..281479 - 294 WP_002481765.1 copper-sensing transcriptional repressor CsoR Antitoxin
CO689_RS02360 281638..283119 + 1482 WP_002481766.1 cardiolipin synthase -
CO689_RS02365 283143..283793 + 651 WP_002481767.1 HD domain-containing protein -
CO689_RS02370 283850..284362 - 513 WP_002481768.1 GNAT family N-acetyltransferase -
CO689_RS02375 284488..285357 - 870 WP_002481769.1 membrane protein insertase YidC -
CO689_RS02380 285446..286084 - 639 WP_002481770.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-65)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7861.82 Da        Isoelectric Point: 4.2670

>T81389 WP_002481764.1 NZ_CP023497:c281171-280965 [Staphylococcus simulans]
MHSSVIQISGMETEEQQHILQEHLQQMIGMSEVQVDLKSQEVKASYQTPISLNNLEKEIYDQGYQILN

Download         Length: 207 bp

>T81389 NZ_CP023497:c281171-280965 [Staphylococcus simulans]
ATGCATAGTAGTGTGATTCAAATCAGTGGTATGGAAACTGAAGAACAACAGCATATTTTGCAAGAACATTTGCAGCAAAT
GATTGGTATGTCAGAAGTGCAAGTGGATCTGAAATCACAAGAAGTGAAAGCGAGTTACCAGACACCAATCAGTTTAAACA
ATTTGGAAAAAGAAATTTATGATCAAGGTTACCAAATATTAAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11033.69 Da        Isoelectric Point: 6.9688

>AT81389 WP_002481765.1 NZ_CP023497:c281479-281186 [Staphylococcus simulans]
MTQEERAHHSEKIKSNLKARLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVAVKLLDHHMKGCILHKAEDGQA
EAAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT81389 NZ_CP023497:c281479-281186 [Staphylococcus simulans]
ATGACGCAAGAAGAACGCGCACATCATTCAGAAAAAATAAAATCTAACCTTAAAGCACGACTGAATCGTATAGAAGGACA
AGTCAGAGCGATTAATCGCATGATAGATGAAGATGTTTATTGTGATGATGTTTTAACACAAATCAGAGCGACACGTTCAG
CTTTGAATAGTGTTGCTGTAAAATTGCTGGATCATCATATGAAAGGCTGTATTTTGCATAAAGCTGAAGATGGACAAGCA
GAAGCTGCAATGGAAGAATTATTAGTTACCGTCCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133QQ97

Antitoxin

Source ID Structure
AlphaFold DB A0A133QQA1

References