81388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 266183..266697 Replicon chromosome
Accession NZ_CP023497
Organism Staphylococcus simulans strain FDAARGOS_383

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CO689_RS02275 Protein ID WP_031262808.1
Coordinates 266183..266533 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CO689_RS02280 Protein ID WP_096754318.1
Coordinates 266530..266697 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO689_RS02255 263266..264036 - 771 WP_002481747.1 RNA polymerase sigma factor SigB -
CO689_RS02260 264011..264487 - 477 WP_096754316.1 anti-sigma B factor RsbW -
CO689_RS02265 264489..264815 - 327 WP_002481749.1 anti-sigma factor antagonist -
CO689_RS02270 264890..265891 - 1002 WP_096754317.1 PP2C family protein-serine/threonine phosphatase -
CO689_RS02275 266183..266533 - 351 WP_031262808.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CO689_RS02280 266530..266697 - 168 WP_096754318.1 antitoxin MazE Antitoxin
CO689_RS02285 266778..267932 - 1155 WP_002481752.1 alanine racemase -
CO689_RS02290 268012..268365 - 354 WP_031262810.1 holo-ACP synthase -
CO689_RS02295 268367..268855 - 489 WP_105165371.1 PH domain-containing protein -
CO689_RS02300 268857..270350 - 1494 WP_002481755.1 PH domain-containing protein -
CO689_RS02305 270343..270807 - 465 WP_060804059.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.09 Da        Isoelectric Point: 10.0474

>T81388 WP_031262808.1 NZ_CP023497:c266533-266183 [Staphylococcus simulans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIGISLGLTHKN

Download         Length: 351 bp

>T81388 NZ_CP023497:c266533-266183 [Staphylococcus simulans]
ATGATGAGGAGAGGCGATGTTTATTTAGCTGATTTATCACCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGACCTGTTGT
AATTATACAAAATGACACTGGCAATAAGTACAGTCCGACGGTAATTGTAGCCGCGATTACTGGGCGTATTAATAAGGCGA
AAATTCCAACACATGTTGAAATTGAAAAGAGTAAATACAAATTAGACAAAGATTCTGTTATATTACTTGAACAGATTAGA
ACAGTTGATAAAAAACGTTTGAAAGAGAAATTGACTTATCTTTCAGATGAGAAGATGAAGGAAATTGATAACGCGATTGG
AATTAGTTTAGGCTTGACACATAAAAATTAG

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6275.81 Da        Isoelectric Point: 3.6836

>AT81388 WP_096754318.1 NZ_CP023497:c266697-266530 [Staphylococcus simulans]
MSTFNQNRSYSMEQSLKEGYSQMADLNLSLATEAFSVECEACDCNESYLTFDKDE

Download         Length: 168 bp

>AT81388 NZ_CP023497:c266697-266530 [Staphylococcus simulans]
ATGTCAACTTTTAATCAGAATAGAAGCTATAGTATGGAACAGTCATTAAAAGAAGGCTATTCACAAATGGCTGATTTGAA
TCTCTCCCTAGCAACGGAGGCATTTTCAGTGGAATGTGAAGCCTGTGATTGCAATGAATCTTATCTTACATTTGATAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References