Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1981532..1982081 | Replicon | chromosome |
| Accession | NZ_CP023485 | ||
| Organism | Vibrio parahaemolyticus strain FORC_071 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A854GNW5 |
| Locus tag | FORC71_RS10095 | Protein ID | WP_025527257.1 |
| Coordinates | 1981782..1982081 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | FORC71_RS10090 | Protein ID | WP_065780721.1 |
| Coordinates | 1981532..1981774 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC71_RS10045 | 1976797..1976889 | - | 93 | WP_077200619.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10050 | 1976916..1977500 | - | 585 | WP_120416735.1 | hypothetical protein | - |
| FORC71_RS25790 | 1977530..1977643 | - | 114 | WP_193251011.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10070 | 1978188..1979228 | - | 1041 | WP_120416736.1 | DUF4062 domain-containing protein | - |
| FORC71_RS10075 | 1979359..1980693 | - | 1335 | WP_120416737.1 | hypothetical protein | - |
| FORC71_RS10080 | 1980751..1980843 | - | 93 | WP_071652217.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10085 | 1980868..1981290 | - | 423 | WP_120416738.1 | hypothetical protein | - |
| FORC71_RS10090 | 1981532..1981774 | + | 243 | WP_065780721.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC71_RS10095 | 1981782..1982081 | + | 300 | WP_025527257.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC71_RS10100 | 1982145..1982237 | - | 93 | WP_080286082.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10105 | 1982276..1982866 | - | 591 | WP_025611578.1 | cold shock and DUF1294 domain-containing protein | - |
| FORC71_RS10110 | 1982909..1982998 | - | 90 | WP_072828858.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10115 | 1983376..1983465 | - | 90 | WP_120416857.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10120 | 1983483..1983791 | - | 309 | WP_025611619.1 | hypothetical protein | - |
| FORC71_RS10125 | 1984549..1984863 | - | 315 | WP_065780693.1 | hypothetical protein | - |
| FORC71_RS10130 | 1984890..1985012 | - | 123 | WP_120416739.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10135 | 1985284..1985376 | - | 93 | WP_120416858.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10140 | 1985419..1985811 | - | 393 | WP_120416740.1 | hypothetical protein | - |
| FORC71_RS10145 | 1985922..1986044 | - | 123 | WP_120416741.1 | DUF3265 domain-containing protein | - |
| FORC71_RS10150 | 1986041..1986340 | - | 300 | WP_120416742.1 | hypothetical protein | - |
| FORC71_RS10155 | 1986368..1986460 | - | 93 | WP_080252013.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1856333..1989263 | 132930 | |
| - | inside | Integron | - | - | 1927077..1988138 | 61061 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11573.18 Da Isoelectric Point: 8.0265
>T81366 WP_025527257.1 NZ_CP023485:1981782-1982081 [Vibrio parahaemolyticus]
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFYFPIGKHTAYFIKEDD
FILVVAVLGQSQLPQNHLK
MQKNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFYFPIGKHTAYFIKEDD
FILVVAVLGQSQLPQNHLK
Download Length: 300 bp
>T81366 NZ_CP023485:1981782-1982081 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9061.29 Da Isoelectric Point: 5.6926
>AT81366 WP_065780721.1 NZ_CP023485:1981532-1981774 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVIVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVIVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
Download Length: 243 bp
>AT81366 NZ_CP023485:1981532-1981774 [Vibrio parahaemolyticus]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCATTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGTGAAAGCTTTCTGAACTCGCTG
TAA
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTGAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCATTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGTGAAAGCTTTCTGAACTCGCTG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|