Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1971565..1972093 Replicon chromosome
Accession NZ_CP023485
Organism Vibrio parahaemolyticus strain FORC_071

Toxin (Protein)


Gene name relE Uniprot ID A0A151KYZ5
Locus tag FORC71_RS09985 Protein ID WP_025536831.1
Coordinates 1971803..1972093 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FORC71_RS09980 Protein ID WP_005377003.1
Coordinates 1971565..1971813 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC71_RS09925 1966827..1966889 - 63 WP_079749016.1 DUF3265 domain-containing protein -
FORC71_RS09930 1966904..1967323 - 420 WP_025441693.1 GNAT family N-acetyltransferase -
FORC71_RS09935 1967781..1967873 - 93 WP_005531022.1 DUF3265 domain-containing protein -
FORC71_RS09940 1967888..1968298 - 411 WP_086459357.1 cytidine deaminase -
FORC71_RS09945 1968449..1968769 - 321 WP_045415786.1 DUF2834 domain-containing protein -
FORC71_RS09950 1969362..1969455 - 94 Protein_1810 DUF3265 domain-containing protein -
FORC71_RS09955 1969470..1970156 - 687 WP_065780677.1 hypothetical protein -
FORC71_RS09960 1970180..1970323 - 144 WP_080540085.1 DUF3265 domain-containing protein -
FORC71_RS09965 1970286..1970762 - 477 WP_021704949.1 GNAT family N-acetyltransferase -
FORC71_RS09970 1970796..1970913 - 118 Protein_1814 DUF3265 domain-containing protein -
FORC71_RS09975 1970904..1971356 - 453 WP_120416733.1 hypothetical protein -
FORC71_RS09980 1971565..1971813 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC71_RS09985 1971803..1972093 + 291 WP_025536831.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC71_RS09990 1972071..1972223 - 153 WP_120416734.1 DUF3265 domain-containing protein -
FORC71_RS09995 1972220..1972558 - 339 WP_086459346.1 hypothetical protein -
FORC71_RS10000 1972706..1973260 - 555 WP_069547737.1 hypothetical protein -
FORC71_RS10005 1973774..1973902 - 129 WP_120416856.1 DUF3265 domain-containing protein -
FORC71_RS10015 1974382..1974669 - 288 WP_065780667.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC71_RS10020 1974666..1974947 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC71_RS10025 1975113..1975547 - 435 WP_029811088.1 hypothetical protein -
FORC71_RS10030 1975757..1976149 - 393 WP_025502499.1 nuclear transport factor 2 family protein -
FORC71_RS10035 1976178..1976309 - 132 WP_086585508.1 DUF3265 domain-containing protein -
FORC71_RS10045 1976797..1976889 - 93 WP_077200619.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1856333..1989263 132930
- inside Integron - - 1927077..1988138 61061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11245.25 Da        Isoelectric Point: 10.5932

>T81364 WP_025536831.1 NZ_CP023485:1971803-1972093 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPAAKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T81364 NZ_CP023485:1971803-1972093 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTGCAAAGCTTTCTGGAGCTGATAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCTGTCGGGAAA
CGCGAACGTAGCGATGTTTACCGTAAGGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT81364 WP_005377003.1 NZ_CP023485:1971565-1971813 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT81364 NZ_CP023485:1971565-1971813 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTGCTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCATACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151KYZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References