Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1947523..1948051 | Replicon | chromosome |
| Accession | NZ_CP023485 | ||
| Organism | Vibrio parahaemolyticus strain FORC_071 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | K5TRR0 |
| Locus tag | FORC71_RS09710 | Protein ID | WP_005377002.1 |
| Coordinates | 1947761..1948051 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | FORC71_RS09705 | Protein ID | WP_005377003.1 |
| Coordinates | 1947523..1947771 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC71_RS09650 | 1942893..1943378 | - | 486 | WP_065780552.1 | GNAT family N-acetyltransferase | - |
| FORC71_RS09655 | 1943442..1943531 | - | 90 | WP_077201254.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09665 | 1944169..1945029 | - | 861 | WP_065780714.1 | hypothetical protein | - |
| FORC71_RS09670 | 1945190..1945594 | - | 405 | WP_065780733.1 | DUF1801 domain-containing protein | - |
| FORC71_RS09680 | 1946068..1946157 | - | 90 | WP_079852371.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09690 | 1946616..1946708 | - | 93 | WP_005500330.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09695 | 1946727..1947329 | - | 603 | WP_065780712.1 | hypothetical protein | - |
| FORC71_RS25925 | 1947380..1947448 | - | 69 | WP_074531725.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09705 | 1947523..1947771 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC71_RS09710 | 1947761..1948051 | + | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC71_RS09715 | 1948157..1949242 | - | 1086 | WP_065780710.1 | SH3 domain-containing protein | - |
| FORC71_RS09720 | 1949385..1949927 | - | 543 | WP_042765806.1 | GNAT family N-acetyltransferase | - |
| FORC71_RS09730 | 1950442..1950535 | - | 94 | Protein_1770 | DUF3265 domain-containing protein | - |
| FORC71_RS09735 | 1950557..1950967 | - | 411 | WP_120416726.1 | hypothetical protein | - |
| FORC71_RS09740 | 1951073..1951165 | - | 93 | Protein_1772 | DUF3265 domain-containing protein | - |
| FORC71_RS09745 | 1951200..1951601 | - | 402 | WP_029807766.1 | HIT family protein | - |
| FORC71_RS09750 | 1951634..1951726 | - | 93 | WP_079852366.1 | DUF3265 domain-containing protein | - |
| FORC71_RS25930 | 1952299..1952589 | - | 291 | WP_065780751.1 | hypothetical protein | - |
| FORC71_RS25935 | 1952596..1952766 | - | 171 | WP_202817281.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1856333..1989263 | 132930 | |
| - | inside | Integron | - | - | 1927077..1988138 | 61061 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11261.25 Da Isoelectric Point: 10.5932
>T81363 WP_005377002.1 NZ_CP023485:1947761-1948051 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T81363 NZ_CP023485:1947761-1948051 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT81363 WP_005377003.1 NZ_CP023485:1947523-1947771 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT81363 NZ_CP023485:1947523-1947771 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR02 |