Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1947523..1948051 Replicon chromosome
Accession NZ_CP023485
Organism Vibrio parahaemolyticus strain FORC_071

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag FORC71_RS09710 Protein ID WP_005377002.1
Coordinates 1947761..1948051 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag FORC71_RS09705 Protein ID WP_005377003.1
Coordinates 1947523..1947771 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC71_RS09650 1942893..1943378 - 486 WP_065780552.1 GNAT family N-acetyltransferase -
FORC71_RS09655 1943442..1943531 - 90 WP_077201254.1 DUF3265 domain-containing protein -
FORC71_RS09665 1944169..1945029 - 861 WP_065780714.1 hypothetical protein -
FORC71_RS09670 1945190..1945594 - 405 WP_065780733.1 DUF1801 domain-containing protein -
FORC71_RS09680 1946068..1946157 - 90 WP_079852371.1 DUF3265 domain-containing protein -
FORC71_RS09690 1946616..1946708 - 93 WP_005500330.1 DUF3265 domain-containing protein -
FORC71_RS09695 1946727..1947329 - 603 WP_065780712.1 hypothetical protein -
FORC71_RS25925 1947380..1947448 - 69 WP_074531725.1 DUF3265 domain-containing protein -
FORC71_RS09705 1947523..1947771 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC71_RS09710 1947761..1948051 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC71_RS09715 1948157..1949242 - 1086 WP_065780710.1 SH3 domain-containing protein -
FORC71_RS09720 1949385..1949927 - 543 WP_042765806.1 GNAT family N-acetyltransferase -
FORC71_RS09730 1950442..1950535 - 94 Protein_1770 DUF3265 domain-containing protein -
FORC71_RS09735 1950557..1950967 - 411 WP_120416726.1 hypothetical protein -
FORC71_RS09740 1951073..1951165 - 93 Protein_1772 DUF3265 domain-containing protein -
FORC71_RS09745 1951200..1951601 - 402 WP_029807766.1 HIT family protein -
FORC71_RS09750 1951634..1951726 - 93 WP_079852366.1 DUF3265 domain-containing protein -
FORC71_RS25930 1952299..1952589 - 291 WP_065780751.1 hypothetical protein -
FORC71_RS25935 1952596..1952766 - 171 WP_202817281.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1856333..1989263 132930
- inside Integron - - 1927077..1988138 61061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T81363 WP_005377002.1 NZ_CP023485:1947761-1948051 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T81363 NZ_CP023485:1947761-1948051 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT81363 WP_005377003.1 NZ_CP023485:1947523-1947771 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT81363 NZ_CP023485:1947523-1947771 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References