Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1935599..1936158 | Replicon | chromosome |
| Accession | NZ_CP023485 | ||
| Organism | Vibrio parahaemolyticus strain FORC_071 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | FORC71_RS09580 | Protein ID | WP_005398411.1 |
| Coordinates | 1935880..1936158 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | FORC71_RS09575 | Protein ID | WP_005398409.1 |
| Coordinates | 1935599..1935883 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC71_RS09540 | 1931316..1931453 | - | 138 | WP_162931994.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09545 | 1931915..1932002 | - | 88 | Protein_1738 | DUF3265 domain-containing protein | - |
| FORC71_RS09550 | 1932020..1932328 | - | 309 | WP_025611619.1 | hypothetical protein | - |
| FORC71_RS09555 | 1932451..1933236 | - | 786 | WP_065780749.1 | hypothetical protein | - |
| FORC71_RS09560 | 1933921..1934328 | - | 408 | WP_031848396.1 | OsmC family protein | - |
| FORC71_RS09565 | 1934486..1934914 | - | 429 | WP_065780738.1 | hypothetical protein | - |
| FORC71_RS25770 | 1935431..1935522 | - | 92 | Protein_1743 | DUF3265 domain-containing protein | - |
| FORC71_RS09575 | 1935599..1935883 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| FORC71_RS09580 | 1935880..1936158 | + | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| FORC71_RS09585 | 1936309..1936812 | - | 504 | WP_045480152.1 | peptide deformylase | - |
| FORC71_RS09595 | 1937478..1937762 | - | 285 | WP_120416855.1 | hypothetical protein | - |
| FORC71_RS09600 | 1938062..1938508 | - | 447 | WP_065780753.1 | GNAT family N-acetyltransferase | - |
| FORC71_RS09605 | 1938538..1938630 | - | 93 | WP_079852374.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09610 | 1938664..1939080 | - | 417 | WP_065780725.1 | DUF1311 domain-containing protein | - |
| FORC71_RS09615 | 1939110..1939250 | - | 141 | WP_079852337.1 | DUF3265 domain-containing protein | - |
| FORC71_RS09620 | 1939225..1939692 | - | 468 | WP_065780546.1 | NUDIX domain-containing protein | - |
| FORC71_RS09625 | 1939867..1940088 | - | 222 | WP_025625227.1 | hypothetical protein | - |
| FORC71_RS09630 | 1940250..1940999 | - | 750 | WP_065780547.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1856333..1989263 | 132930 | |
| - | inside | Integron | - | - | 1927077..1988138 | 61061 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T81362 WP_005398411.1 NZ_CP023485:1935880-1936158 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T81362 NZ_CP023485:1935880-1936158 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT81362 WP_005398409.1 NZ_CP023485:1935599-1935883 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT81362 NZ_CP023485:1935599-1935883 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGTAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGTAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR22 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |