Detailed information of TA system TA081360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3551394..3552028
• Replicon: chromosome
• Accession: NZ_CP023484
• Organism: Dickeya sp. Secpp 1600

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CPA59_RS15720
• Protein ID: WP_038919729.1
• Coordinates: 3551624..3552028 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CPA59_RS15715
• Protein ID: WP_038919728.1
• Coordinates: 3551394..3551624 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPA59_RS15700	3548337..3549445	+	1109	Protein_3031	IS3 family transposase	-
CPA59_RS15710	3549639..3551210	-	1572	WP_049842570.1	DUF2235 domain-containing protein	-
CPA59_RS15715	3551394..3551624	+	231	WP_038919728.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CPA59_RS15720	3551624..3552028	+	405	WP_038919729.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CPA59_RS15725	3552053..3553047	-	995	Protein_3035	IS3 family transposase	-
CPA59_RS15730	3553114..3554136	+	1023	WP_100848778.1	IS110 family transposase	-
CPA59_RS15735	3554355..3554471	-	117	Protein_3037	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3549092..3564462	15370
	-	inside	IScluster/Tn	-	-	3548337..3554471	6134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15085.32 Da
• Isoelectric Point: 7.9926

>T81360 WP_038919729.1 NZ_CP023484:3551624-3552028 [Dickeya sp. Secpp 1600]
MLKYLLDTNICIYTIKNKPQEVRDAFYRYYGQFAISAITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQTYGFDAAVHT
GQIRAELARQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVSR

Nucleotide

• Length: 405 bp

>T81360 NZ_CP023484:3551624-3552028 [Dickeya sp. Secpp 1600]
ATGCTGAAATATCTGCTTGATACCAATATCTGTATTTACACCATCAAGAACAAACCACAGGAAGTCAGGGACGCTTTCTA
CCGTTATTACGGGCAGTTTGCTATCAGTGCTATCACGCTGATGGAGCTGATTTATGGCGCGGAGAAATCGGTAAACCCAG
AAAAGAATCTTGCCGTGATTGAAGGGTTTTCTGCGCGTCTGGAAGTGCAAACCTATGGTTTTGACGCTGCCGTGCATACC
GGCCAAATTCGTGCGGAACTGGCAAGACAAGGAACCCCCATCGGCCCATATGATGCCATGCTAGCGGGTCACGCTCGATC
AGCAGGTTTGATACTGGTAACGAACAATGTGCGTGAATTTGAGCGTGTGCCTGGGCTACGAGTGGAAAACTGGGTCAGTC
GATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8708.78 Da
• Isoelectric Point: 4.3193

>AT81360 WP_038919728.1 NZ_CP023484:3551394-3551624 [Dickeya sp. Secpp 1600]
MEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIITPAGESWDSWFEEEGVTPDFMITREQPDDQIREDF

Nucleotide

• Length: 231 bp

>AT81360 NZ_CP023484:3551394-3551624 [Dickeya sp. Secpp 1600]
ATGGAAAAAACCACAGTATTTAAAAGCAATCGCAGTCAAGCAGTACGACTCCCCAAAGCCGTTGCACTGCCCGATGATGT
TAAGCAGGTTGATATCGTCGCGATTGGTCGCACACGTATCATTACTCCGGCAGGCGAAAGCTGGGACAGTTGGTTCGAAG
AGGAAGGGGTAACGCCTGACTTCATGATCACCAGAGAGCAACCCGATGATCAGATCAGGGAAGATTTCTGA