Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1229400..1230025 Replicon chromosome
Accession NZ_CP023484
Organism Dickeya sp. Secpp 1600

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag CPA59_RS05625 Protein ID WP_009114000.1
Coordinates 1229400..1229603 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag CPA59_RS05630 Protein ID WP_042859087.1
Coordinates 1229657..1230025 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPA59_RS05595 1225039..1225377 + 339 WP_002208627.1 P-II family nitrogen regulator -
CPA59_RS05600 1225420..1226712 + 1293 WP_038661206.1 ammonium transporter AmtB -
CPA59_RS05605 1226805..1227668 - 864 WP_049854164.1 acyl-CoA thioesterase II -
CPA59_RS05610 1227921..1228481 + 561 WP_049854165.1 YbaY family lipoprotein -
CPA59_RS05615 1228510..1228839 - 330 WP_038918197.1 MGMT family protein -
CPA59_RS05625 1229400..1229603 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
CPA59_RS05630 1229657..1230025 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
CPA59_RS05635 1230533..1230676 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
CPA59_RS05640 1230692..1230943 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
CPA59_RS05645 1231115..1234261 - 3147 WP_038918200.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T81349 WP_009114000.1 NZ_CP023484:c1229603-1229400 [Dickeya sp. Secpp 1600]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T81349 NZ_CP023484:c1229603-1229400 [Dickeya sp. Secpp 1600]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCAACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT81349 WP_042859087.1 NZ_CP023484:c1230025-1229657 [Dickeya sp. Secpp 1600]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT81349 NZ_CP023484:c1230025-1229657 [Dickeya sp. Secpp 1600]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACTCCGAGTTGCAGAAATGGAAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References