Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 720786..721464 Replicon chromosome
Accession NZ_CP023484
Organism Dickeya sp. Secpp 1600

Toxin (Protein)


Gene name cptA Uniprot ID A0A2K8QJH4
Locus tag CPA59_RS03400 Protein ID WP_049854564.1
Coordinates 721033..721464 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K8QSU7
Locus tag CPA59_RS03395 Protein ID WP_023637600.1
Coordinates 720786..721052 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPA59_RS03375 717232..717882 + 651 WP_049854566.1 LysE family translocator -
CPA59_RS03380 717953..718561 - 609 WP_038917841.1 HD domain-containing protein -
CPA59_RS03385 718772..719422 + 651 WP_038917842.1 hemolysin III family protein -
CPA59_RS03390 719495..720475 - 981 WP_107758697.1 tRNA-modifying protein YgfZ -
CPA59_RS03395 720786..721052 + 267 WP_023637600.1 FAD assembly factor SdhE Antitoxin
CPA59_RS03400 721033..721464 + 432 WP_049854564.1 protein YgfX Toxin
CPA59_RS03405 721563..722081 - 519 WP_107758698.1 flavodoxin FldB -
CPA59_RS03410 722210..723535 - 1326 WP_107758699.1 MHS family MFS transporter -
CPA59_RS03415 723798..724697 + 900 WP_038917846.1 site-specific tyrosine recombinase XerD -
CPA59_RS03420 724786..725502 + 717 WP_049854562.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16793.54 Da        Isoelectric Point: 11.7737

>T81347 WP_049854564.1 NZ_CP023484:721033-721464 [Dickeya sp. Secpp 1600]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLLQHPLQGTESSRHH

Download         Length: 432 bp

>T81347 NZ_CP023484:721033-721464 [Dickeya sp. Secpp 1600]
GTGGCCCAGTGGCAATGTGATTTGCGTGTATCCTGGCGCATGCAGTTGTTTTCTCTGCTGACGCACGGGTTCCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACCGGTAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAACTGTTGCTGCAGCATCCGC
TGCAGGGCACGGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.03 Da        Isoelectric Point: 5.5535

>AT81347 WP_023637600.1 NZ_CP023484:720786-721052 [Dickeya sp. Secpp 1600]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT81347 NZ_CP023484:720786-721052 [Dickeya sp. Secpp 1600]
ATGGACATCAATAACAAATCACGCATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATTTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGTGGATCCGGAACTGAAGCGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QJH4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QSU7

References