Detailed information of TA system TA081346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 592282..592808
• Replicon: chromosome
• Accession: NZ_CP023484
• Organism: Dickeya sp. Secpp 1600

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: CPA59_RS02765
• Protein ID: WP_107758661.1
• Coordinates: 592282..592587 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: C6C380
• Locus tag: CPA59_RS02770
• Protein ID: WP_015855076.1
• Coordinates: 592590..592808 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPA59_RS02745	587451..587945	+	495	WP_094107695.1	GNAT family N-acetyltransferase	-
CPA59_RS02750	588068..589339	+	1272	WP_159077918.1	hypothetical protein	-
CPA59_RS02755	589343..589879	+	537	WP_107758659.1	hypothetical protein	-
CPA59_RS02760	589867..591807	+	1941	WP_107758660.1	hypothetical protein	-
CPA59_RS02765	592282..592587	-	306	WP_107758661.1	type II toxin-antitoxin system toxin CcdB	Toxin
CPA59_RS02770	592590..592808	-	219	WP_015855076.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
CPA59_RS02775	592867..593610	-	744	WP_107758662.1	molybdopterin-guanine dinucleotide biosynthesis protein MobC	-
CPA59_RS02785	594517..594858	-	342	WP_107760759.1	hypothetical protein	-
CPA59_RS02790	595044..595238	+	195	WP_010299634.1	DUF3950 domain-containing protein	-
CPA59_RS02795	595345..596604	-	1260	WP_107758664.1	integrase arm-type DNA-binding domain-containing protein	-
CPA59_RS02805	597004..597579	-	576	WP_038917759.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	586905..596781	9876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11806.71 Da
• Isoelectric Point: 4.8616

>T81346 WP_107758661.1 NZ_CP023484:c592587-592282 [Dickeya sp. Secpp 1600]
MQFIVYQYKRTSHYKMFVDVQSDIVETPKRRMAIPLIEAHHLSEKVNKMLFPLLRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGNYADEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T81346 NZ_CP023484:c592587-592282 [Dickeya sp. Secpp 1600]
ATGCAATTCATTGTTTATCAATACAAACGTACCAGCCACTACAAAATGTTTGTCGATGTGCAGAGTGATATTGTCGAGAC
ACCCAAGCGGCGCATGGCCATTCCGCTTATCGAAGCACATCATCTGTCTGAGAAAGTGAATAAGATGTTGTTCCCTCTGC
TTCGCATCGATGGCGAAGATTATCGGTTGATGACAACTGAACTATCGAGCGTTCCTGTTGAGGTTATTGGTGAAGAAATC
GCGGATCTTGGCAACTACGCTGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8178.13 Da
• Isoelectric Point: 7.0135

>AT81346 WP_015855076.1 NZ_CP023484:c592808-592590 [Dickeya sp. Secpp 1600]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT81346 NZ_CP023484:c592808-592590 [Dickeya sp. Secpp 1600]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A250BG46