Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3632868..3633504 Replicon chromosome
Accession NZ_CP023481
Organism Bacillus glycinifermentans strain KBN06P03352

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag COP00_RS19055 Protein ID WP_003179128.1
Coordinates 3633154..3633504 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6I7F8B4
Locus tag COP00_RS19050 Protein ID WP_026585993.1
Coordinates 3632868..3633149 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COP00_RS19030 3628029..3629510 + 1482 WP_048356046.1 PH domain-containing protein -
COP00_RS19035 3629507..3630106 - 600 WP_048356047.1 rhomboid family intramembrane serine protease -
COP00_RS19040 3630388..3631404 + 1017 WP_096892205.1 outer membrane lipoprotein carrier protein LolA -
COP00_RS19045 3631599..3632759 + 1161 WP_048406138.1 alanine racemase -
COP00_RS19050 3632868..3633149 + 282 WP_026585993.1 hypothetical protein Antitoxin
COP00_RS19055 3633154..3633504 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
COP00_RS19060 3633579..3634448 + 870 WP_172796307.1 STAS domain-containing protein -
COP00_RS19065 3634451..3634816 + 366 WP_046132197.1 STAS domain-containing protein -
COP00_RS19070 3634819..3635219 + 401 Protein_3705 anti-sigma regulatory factor -
COP00_RS19075 3635230..3636237 + 1008 WP_048356050.1 PP2C family protein-serine/threonine phosphatase -
COP00_RS19080 3636296..3636622 + 327 WP_048356051.1 anti-sigma factor antagonist -
COP00_RS19085 3636622..3637104 + 483 WP_046132193.1 anti-sigma B factor RsbW -
COP00_RS19090 3637070..3637861 + 792 WP_057957415.1 RNA polymerase sigma factor SigB -
COP00_RS19095 3637858..3638457 + 600 WP_096891990.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T81339 WP_003179128.1 NZ_CP023481:3633154-3633504 [Bacillus glycinifermentans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T81339 NZ_CP023481:3633154-3633504 [Bacillus glycinifermentans]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTATGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATC
CGGACGATTGATAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTTAACGAAGCCTT
ACAAATCAGTTTGGCACTAATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10667.07 Da        Isoelectric Point: 4.6920

>AT81339 WP_026585993.1 NZ_CP023481:3632868-3633149 [Bacillus glycinifermentans]
MSESSATTEIMIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT81339 NZ_CP023481:3632868-3633149 [Bacillus glycinifermentans]
TTGTCTGAATCCAGCGCTACAACTGAAATTATGATTCGCTTGCCAGAAGCCTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCCGAAATGAACTGATTTATCAAGCCACAAAAATGTATTTACGTGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCAAAAATCAATTTAAACATCTCCTCAGAGGCACAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7F8B4

References