Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743816..744591 Replicon chromosome
Accession NZ_CP023478
Organism Klebsiella quasipneumoniae strain KPC142

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag KPC142_RS03815 Protein ID WP_049092700.1
Coordinates 744106..744591 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag KPC142_RS03810 Protein ID WP_049092701.1
Coordinates 743816..744109 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPC142_RS03790 739019..739621 - 603 WP_106938678.1 short chain dehydrogenase -
KPC142_RS03795 739719..740630 + 912 WP_087833146.1 LysR family transcriptional regulator -
KPC142_RS03800 740631..741779 - 1149 WP_106938679.1 PLP-dependent aspartate aminotransferase family protein -
KPC142_RS03805 741790..743166 - 1377 WP_192870149.1 pyridoxal-phosphate dependent enzyme -
KPC142_RS03810 743816..744109 + 294 WP_049092701.1 DUF1778 domain-containing protein Antitoxin
KPC142_RS03815 744106..744591 + 486 WP_049092700.1 GNAT family N-acetyltransferase Toxin
KPC142_RS03820 744770..745222 - 453 WP_049014234.1 hypothetical protein -
KPC142_RS03825 745307..745555 - 249 WP_106938680.1 hypothetical protein -
KPC142_RS03830 745727..748012 - 2286 WP_106939615.1 hypothetical protein -
KPC142_RS27285 748141..749170 - 1030 Protein_723 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 738200..750830 12630
- flank IS/Tn - - 749250..750173 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17471.39 Da        Isoelectric Point: 8.1467

>T81323 WP_049092700.1 NZ_CP023478:744106-744591 [Klebsiella quasipneumoniae]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMMLMVTLGDLVN
A

Download         Length: 486 bp

>T81323 NZ_CP023478:744106-744591 [Klebsiella quasipneumoniae]
ATGATCTCCGCTCCAGAACCGCTTCATACCGGGCATATTCTTACCCCGTTTTGTTGCGGCGTGGATTCTATGGATAACTG
GCTAAAACAGCGGGCGATGAAGAACCAGCTTTCTGGCGCATCCCGCACGTTCGTCTGCTGTGACGATGCGAAGGTAATGG
CGTACTACTCGCTGGCTTCAAGTGCTGTGACGACAAATACTGCGCCCGGTCGCTTCCGTCGCAATATGCCTGACCCGATC
CCGGTTGTGGTGCTGGGACGTCTGGCGGTGGATAAATCGCTGCATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
TGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCTCGAG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCTATAGATCCGATGATGCTGATGGTGACATTGGGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10972.58 Da        Isoelectric Point: 8.6141

>AT81323 WP_049092701.1 NZ_CP023478:743816-744109 [Klebsiella quasipneumoniae]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT81323 NZ_CP023478:743816-744109 [Klebsiella quasipneumoniae]
ATGCCAGCCGCAAACAGTATGACGATGAAACGCGAAACCTTGAATCTGCGCATCAAGCCCGCCGAGCGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGAGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATTATTTTGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGAGCCCAAT
GCCGCATTGCGTAAAACCATGCAGACCCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References