Detailed information of TA system TA081322

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 742907..743493
• Replicon: chromosome
• Accession: NZ_CP023477
• Organism: Streptococcus mutans strain LAR01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CO204_RS03885
• Protein ID: WP_002265423.1
• Coordinates: 742907..743098 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CO204_RS03890
• Protein ID: WP_002264915.1
• Coordinates: 743116..743493 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO204_RS03870	740951..741817	+	867	WP_002269449.1	type II CRISPR-associated endonuclease Cas1	-
CO204_RS03875	741814..742158	+	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
CO204_RS03880	742148..742810	+	663	WP_002280936.1	type II-A CRISPR-associated protein Csn2	-
CO204_RS03885	742907..743098	+	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
CO204_RS03890	743116..743493	+	378	WP_002264915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CO204_RS03895	746141..747034	-	894	WP_002272311.1	LexA family transcriptional regulator IrvR	-
CO204_RS03900	747350..747634	+	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T81322 WP_002265423.1 NZ_CP023477:742907-743098 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T81322 NZ_CP023477:742907-743098 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14307.31 Da
• Isoelectric Point: 4.5628

>AT81322 WP_002264915.1 NZ_CP023477:743116-743493 [Streptococcus mutans]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT81322 NZ_CP023477:743116-743493 [Streptococcus mutans]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGATATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA