Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 191781..192352 Replicon chromosome
Accession NZ_CP023477
Organism Streptococcus mutans strain LAR01

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag CO204_RS01030 Protein ID WP_002262989.1
Coordinates 192020..192352 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag CO204_RS01025 Protein ID WP_002264866.1
Coordinates 191781..192026 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO204_RS01015 187687..189594 + 1908 WP_106006666.1 ATP-binding protein -
CO204_RS01020 189614..191212 + 1599 WP_106006667.1 Abi family protein -
CO204_RS01025 191781..192026 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CO204_RS01030 192020..192352 + 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CO204_RS01035 192550..193341 - 792 WP_002278669.1 nucleotidyltransferase domain-containing protein -
CO204_RS10705 193508..193864 + 357 Protein_174 transposase family protein -
CO204_RS01045 194043..195263 + 1221 WP_002262024.1 PTS sugar transporter subunit IIC -
CO204_RS01050 195241..196089 + 849 WP_019313039.1 alpha/beta hydrolase -
CO204_RS01055 196231..196833 + 603 WP_002274543.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 193508..193636 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T81321 WP_002262989.1 NZ_CP023477:192020-192352 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T81321 NZ_CP023477:192020-192352 [Streptococcus mutans]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCACAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT81321 WP_002264866.1 NZ_CP023477:191781-192026 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT81321 NZ_CP023477:191781-192026 [Streptococcus mutans]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References