Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 179197..179748 Replicon chromosome
Accession NZ_CP023477
Organism Streptococcus mutans strain LAR01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CO204_RS00965 Protein ID WP_106006659.1
Coordinates 179197..179475 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CO204_RS00970 Protein ID WP_106006660.1
Coordinates 179476..179748 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO204_RS00930 175384..175638 - 255 WP_002270995.1 Txe/YoeB family addiction module toxin -
CO204_RS00935 175631..175897 - 267 WP_002270994.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CO204_RS00940 176161..177819 - 1659 WP_106006658.1 cell division protein FtsK -
CO204_RS00945 177826..178236 - 411 WP_002280076.1 DUF961 family protein -
CO204_RS00950 178259..178573 - 315 WP_000406626.1 hypothetical protein -
CO204_RS00960 178912..179148 - 237 WP_002280074.1 hypothetical protein -
CO204_RS00965 179197..179475 - 279 WP_106006659.1 type II toxin-antitoxin system YafQ family toxin Toxin
CO204_RS00970 179476..179748 - 273 WP_106006660.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CO204_RS00975 179900..180613 + 714 WP_106006661.1 hypothetical protein -
CO204_RS00980 181378..181740 + 363 WP_106006662.1 helix-turn-helix transcriptional regulator -
CO204_RS00985 181747..182598 + 852 WP_002280069.1 ImmA/IrrE family metallo-endopeptidase -
CO204_RS00990 182618..182980 - 363 WP_002280068.1 hypothetical protein -
CO204_RS00995 183068..184618 - 1551 WP_106006663.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10982.80 Da        Isoelectric Point: 7.2759

>T81320 WP_106006659.1 NZ_CP023477:c179475-179197 [Streptococcus mutans]
MYQVKFTSAFKKSYKRIKKRGLEIELLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLVYFIEDDILTLTL
VDTGSHADLFKM

Download         Length: 279 bp

>T81320 NZ_CP023477:c179475-179197 [Streptococcus mutans]
ATGTACCAAGTCAAGTTTACCTCTGCTTTTAAAAAGAGCTATAAACGAATTAAAAAGCGAGGTTTAGAGATTGAACTCCT
AGATGAAGTGATTGAAAAACTCCGTCTGGGACAAACACTAGAAGAAAAATACCGTGACCACGAACTCAAAGGAAATTTTG
TTGGTTTTAGGGAATGTCATATTAAACCAGATTGGCTTTTGGTTTATTTTATTGAAGACGATATTTTGACGTTGACTTTG
GTTGATACAGGCAGTCATGCGGATTTATTTAAGATGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9895.37 Da        Isoelectric Point: 4.7247

>AT81320 WP_106006660.1 NZ_CP023477:c179748-179476 [Streptococcus mutans]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEAMAEAKKISRDETVASYDN
LADLKKALEA

Download         Length: 273 bp

>AT81320 NZ_CP023477:c179748-179476 [Streptococcus mutans]
ATGGCAACTGTCCCAACACAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGTAT
GGATATGTCTAGTGCAGTTAATATTTTTCTTCGTCAATGTTTATTACGTGGTGGCCTTCCTTTTACAGTGGAAGTTCCAA
ATTATAGCCAAAAGACTTTAGAAGCTATGGCAGAAGCTAAGAAGATTTCACGTGATGAAACAGTAGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAAGCTCTGGAAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References