Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 160631..161592 | Replicon | chromosome |
| Accession | NZ_CP023477 | ||
| Organism | Streptococcus mutans strain LAR01 | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | A0A2J9QC39 |
| Locus tag | CO204_RS00825 | Protein ID | WP_002267097.1 |
| Coordinates | 160631..161146 (+) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | - |
| Locus tag | CO204_RS00830 | Protein ID | WP_002297886.1 |
| Coordinates | 161146..161592 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CO204_RS00800 | 156048..156785 | + | 738 | WP_002263001.1 | MerR family transcriptional regulator | - |
| CO204_RS00805 | 156821..157813 | - | 993 | WP_019313036.1 | BtrH N-terminal domain-containing protein | - |
| CO204_RS00810 | 158002..158556 | - | 555 | WP_002275401.1 | helix-turn-helix transcriptional regulator | - |
| CO204_RS00815 | 158869..159615 | + | 747 | WP_002264862.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| CO204_RS00820 | 159639..160499 | + | 861 | WP_019313037.1 | DegV family protein | - |
| CO204_RS00825 | 160631..161146 | + | 516 | WP_002267097.1 | hypothetical protein | Toxin |
| CO204_RS00830 | 161146..161592 | + | 447 | WP_002297886.1 | hypothetical protein | Antitoxin |
| CO204_RS00835 | 161589..161783 | + | 195 | WP_019313038.1 | helix-turn-helix transcriptional regulator | - |
| CO204_RS00845 | 162183..162629 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| CO204_RS00850 | 162654..163046 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| CO204_RS00855 | 163152..164375 | - | 1224 | WP_106006651.1 | site-specific integrase | - |
| CO204_RS00860 | 164430..164702 | - | 273 | WP_002280088.1 | helix-turn-helix domain-containing protein | - |
| CO204_RS00865 | 164814..165146 | - | 333 | WP_106006652.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| CO204_RS00870 | 165133..165438 | - | 306 | WP_106006653.1 | toxin-antitoxin system protein | - |
| CO204_RS00875 | 165495..166550 | - | 1056 | WP_106006654.1 | CHAP domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19512.16 Da Isoelectric Point: 9.8653
>T81318 WP_002267097.1 NZ_CP023477:160631-161146 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T81318 NZ_CP023477:160631-161146 [Streptococcus mutans]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGGGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGGGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 17012.29 Da Isoelectric Point: 9.5767
>AT81318 WP_002297886.1 NZ_CP023477:161146-161592 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIIYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIIYRHYLDKKEADK
Download Length: 447 bp
>AT81318 NZ_CP023477:161146-161592 [Streptococcus mutans]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCATCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACCTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCATCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|