Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1999446..2000005 | Replicon | chromosome |
| Accession | NZ_CP023472 | ||
| Organism | Vibrio parahaemolyticus strain FORC_072 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | FORC72_RS10495 | Protein ID | WP_005398411.1 |
| Coordinates | 1999727..2000005 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | FORC72_RS10490 | Protein ID | WP_005398409.1 |
| Coordinates | 1999446..1999730 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC72_RS10450 | 1994598..1994717 | - | 120 | WP_120459191.1 | DUF3265 domain-containing protein | - |
| FORC72_RS26180 | 1994714..1995058 | - | 345 | WP_029853426.1 | hypothetical protein | - |
| FORC72_RS10455 | 1995196..1995846 | - | 651 | WP_120458890.1 | hypothetical protein | - |
| FORC72_RS10460 | 1995873..1995974 | - | 102 | WP_080261769.1 | DUF3265 domain-containing protein | - |
| FORC72_RS10465 | 1995987..1996454 | - | 468 | WP_029853530.1 | NUDIX domain-containing protein | - |
| FORC72_RS10470 | 1996606..1996971 | - | 366 | WP_025613415.1 | hypothetical protein | - |
| FORC72_RS10475 | 1997172..1997438 | - | 267 | WP_120458891.1 | barstar family protein | - |
| FORC72_RS10480 | 1997480..1997572 | - | 93 | WP_079883235.1 | DUF3265 domain-containing protein | - |
| FORC72_RS10485 | 1997587..1998699 | - | 1113 | Protein_1829 | DUF4236 domain-containing protein | - |
| FORC72_RS26185 | 1998862..1999233 | - | 372 | WP_029853539.1 | hypothetical protein | - |
| FORC72_RS10490 | 1999446..1999730 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| FORC72_RS10495 | 1999727..2000005 | + | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| FORC72_RS10500 | 2000143..2000652 | - | 510 | WP_005500308.1 | ClbS/DfsB family four-helix bundle protein | - |
| FORC72_RS10505 | 2000681..2000773 | - | 93 | WP_078534682.1 | DUF3265 domain-containing protein | - |
| FORC72_RS10510 | 2000796..2001707 | - | 912 | WP_029853452.1 | hypothetical protein | - |
| FORC72_RS10515 | 2001744..2001833 | - | 90 | WP_069545109.1 | DUF3265 domain-containing protein | - |
| FORC72_RS10520 | 2002440..2003330 | - | 891 | WP_005377010.1 | hypothetical protein | - |
| FORC72_RS10530 | 2004052..2004609 | - | 558 | WP_029853488.1 | nucleotidyltransferase family protein | - |
| FORC72_RS10535 | 2004630..2004722 | - | 93 | WP_080261757.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1818293..2129287 | 310994 | |
| - | inside | Integron | - | - | 1917746..2057322 | 139576 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T81315 WP_005398411.1 NZ_CP023472:1999727-2000005 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T81315 NZ_CP023472:1999727-2000005 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAAATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTGGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAAATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAGAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTGGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT81315 WP_005398409.1 NZ_CP023472:1999446-1999730 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT81315 NZ_CP023472:1999446-1999730 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGCAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR22 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |