Detailed information of TA system TA081314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1940178..1940706
• Replicon: chromosome
• Accession: NZ_CP023472
• Organism: Vibrio parahaemolyticus strain FORC_072

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC72_RS09825
• Protein ID: WP_029853447.1
• Coordinates: 1940416..1940706 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: FORC72_RS09820
• Protein ID: WP_005377003.1
• Coordinates: 1940178..1940426 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC72_RS09760	1935350..1935736	-	387	WP_029853366.1	type II toxin-antitoxin system YafO family toxin	-
FORC72_RS09765	1936062..1936592	-	531	WP_049882191.1	hypothetical protein	-
FORC72_RS09770	1936735..1937394	-	660	WP_120458863.1	hypothetical protein	-
FORC72_RS09775	1937425..1937562	-	138	WP_029795349.1	DUF3265 domain-containing protein	-
FORC72_RS26125	1938051..1938233	-	183	WP_162935452.1	hypothetical protein	-
FORC72_RS09800	1938622..1938698	-	77	Protein_1706	DUF3265 domain-containing protein	-
FORC72_RS09805	1938727..1939113	-	387	WP_080536158.1	nuclear transport factor 2 family protein	-
FORC72_RS26130	1939261..1939425	-	165	WP_162836306.1	hypothetical protein	-
FORC72_RS09810	1939427..1939849	-	423	WP_029853484.1	hypothetical protein	-
FORC72_RS09815	1940011..1940103	-	93	WP_072612521.1	DUF3265 domain-containing protein	-
FORC72_RS09820	1940178..1940426	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC72_RS09825	1940416..1940706	+	291	WP_029853447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC72_RS09830	1940725..1940838	-	114	WP_169614726.1	DUF3265 domain-containing protein	-
FORC72_RS09835	1941272..1941361	-	90	WP_079749015.1	DUF3265 domain-containing protein	-
FORC72_RS09840	1941796..1942080	-	285	WP_120458867.1	nucleotide pyrophosphohydrolase	-
FORC72_RS09850	1942618..1942707	-	90	WP_120459189.1	DUF3265 domain-containing protein	-
FORC72_RS09855	1942738..1943091	-	354	WP_029853449.1	hypothetical protein	-
FORC72_RS09860	1943808..1944317	-	510	WP_049882205.1	hypothetical protein	-
FORC72_RS26135	1944350..1944517	-	168	WP_139122825.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1818293..2129287	310994
	-	inside	Integron	-	-	1917746..2057322	139576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11242.20 Da
• Isoelectric Point: 10.5021

>T81314 WP_029853447.1 NZ_CP023472:1940416-1940706 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLHQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T81314 NZ_CP023472:1940416-1940706 [Vibrio parahaemolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCATCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT81314 WP_005377003.1 NZ_CP023472:1940178-1940426 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT81314 NZ_CP023472:1940178-1940426 [Vibrio parahaemolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCCGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR02