Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1926301..1926848 Replicon chromosome
Accession NZ_CP023472
Organism Vibrio parahaemolyticus strain FORC_072

Toxin (Protein)


Gene name relE Uniprot ID A0A7Z2MSV0
Locus tag FORC72_RS09685 Protein ID WP_025527253.1
Coordinates 1926301..1926603 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag FORC72_RS09690 Protein ID WP_005448240.1
Coordinates 1926591..1926848 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC72_RS09640 1921922..1922239 - 318 WP_120458858.1 hypothetical protein -
FORC72_RS09645 1922267..1922359 - 93 WP_075111344.1 DUF3265 domain-containing protein -
FORC72_RS09650 1922470..1922754 + 285 Protein_1680 PAAR domain-containing protein -
FORC72_RS09655 1923412..1923888 + 477 WP_017190371.1 DUF600 family protein -
FORC72_RS09660 1924096..1924503 - 408 WP_025523877.1 OsmC family protein -
FORC72_RS09665 1925034..1925165 - 132 WP_017821410.1 DUF3265 domain-containing protein -
FORC72_RS09675 1925697..1926143 - 447 WP_120458859.1 GNAT family N-acetyltransferase -
FORC72_RS09680 1926173..1926265 - 93 WP_193268597.1 DUF3265 domain-containing protein -
FORC72_RS09685 1926301..1926603 - 303 WP_025527253.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC72_RS09690 1926591..1926848 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC72_RS09695 1927075..1927297 - 223 Protein_1688 hypothetical protein -
FORC72_RS09700 1927402..1927545 - 144 WP_203511651.1 DUF3265 domain-containing protein -
FORC72_RS26120 1928002..1928224 - 223 Protein_1690 hypothetical protein -
FORC72_RS09710 1928488..1928565 - 78 WP_072833152.1 DUF3265 domain-containing protein -
FORC72_RS09715 1928594..1928968 - 375 WP_162935451.1 hypothetical protein -
FORC72_RS09720 1928996..1929073 - 78 WP_080261746.1 DUF3265 domain-containing protein -
FORC72_RS09725 1929107..1929613 - 507 WP_029853444.1 GNAT family N-acetyltransferase -
FORC72_RS09730 1929642..1929734 - 93 WP_120458862.1 DUF3265 domain-containing protein -
FORC72_RS09735 1929749..1931035 - 1287 WP_029853158.1 ImmA/IrrE family metallo-endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1818293..2129287 310994
- inside Integron - - 1917746..2057322 139576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11640.53 Da        Isoelectric Point: 4.8951

>T81313 WP_025527253.1 NZ_CP023472:c1926603-1926301 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T81313 NZ_CP023472:c1926603-1926301 [Vibrio parahaemolyticus]
ATGGCTGAAATAATTTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCTTTTCTAAAGTTGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCAC
CTGAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGCGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGCAAGTTCCTATTGAGCAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT81313 WP_005448240.1 NZ_CP023472:c1926848-1926591 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT81313 NZ_CP023472:c1926848-1926591 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAGATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGCTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2MSV0

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References