Detailed information of TA system TA081309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 54189..54724
• Replicon: plasmid pSalSendai
• Accession: NZ_CP023471
• Organism: Salmonella enterica subsp. enterica strain BAA-1672

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CO195_RS23310
• Protein ID: WP_001270421.1
• Coordinates: 54437..54724 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L4J0V6
• Locus tag: CO195_RS23305
• Protein ID: WP_001132895.1
• Coordinates: 54189..54440 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO195_RS23275	49743..50912	+	1170	WP_117335823.1	transposase	-
CO195_RS23280	50952..51125	+	174	Protein_60	DUF4113 domain-containing protein	-
CO195_RS23285	51266..52228	-	963	WP_048889373.1	ParB/RepB/Spo0J family partition protein	-
CO195_RS23290	52225..53430	-	1206	WP_000817642.1	AAA family ATPase	-
CO195_RS23300	53804..54016	+	213	WP_000402944.1	hypothetical protein	-
CO195_RS23305	54189..54440	+	252	WP_001132895.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CO195_RS23310	54437..54724	+	288	WP_001270421.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CO195_RS23315	54738..54986	+	249	Protein_66	hypothetical protein	-
CO195_RS23320	55011..55301	+	291	WP_048889372.1	hypothetical protein	-
CO195_RS23330	55943..56920	+	978	WP_048889370.1	RepB family plasmid replication initiator protein	-
CO195_RS23335	57181..57381	-	201	Protein_69	hypothetical protein	-
CO195_RS23340	57572..58378	-	807	WP_117335825.1	site-specific integrase	-
CO195_RS23345	58379..58684	-	306	WP_001159866.1	type II toxin-antitoxin system toxin CcdB	-
CO195_RS23350	58686..58904	-	219	WP_000813634.1	type II toxin-antitoxin system antitoxin CcdA	-
CO195_RS23365	59488..59718	+	231	WP_001261287.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81125	81125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 12322.73 Da
• Isoelectric Point: 12.7777

>T81309 WP_001270421.1 NZ_CP023471:54437-54724 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Nucleotide

• Length: 288 bp

>T81309 NZ_CP023471:54437-54724 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT81309 WP_001132895.1 NZ_CP023471:54189-54440 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT81309 NZ_CP023471:54189-54440 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: L4J0V6