Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4991470..4993055 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CO076_RS22630 Protein ID WP_038912333.1
Coordinates 4991736..4993055 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CO076_RS22625 Protein ID WP_033112453.1
Coordinates 4991470..4991736 (+) Length 89 a.a.

Genomic Context

CO076_RS22605CO076_RS22615CO076_RS22620CO076_RS22625CO076_RS22630CO076_RS22600CO076_RS22610CO076_RS22635CO076_RS22640CO076_RS22645CO076_RS22650CO076_RS22655
Location: 4987521..4987901 (381 bp)
Type: Others
Protein ID: WP_038902818.1
Location: 4989426..4990199 (774 bp)
Type: Others
Protein ID: WP_038912336.1
Location: 4990242..4991198 (957 bp)
Type: Others
Protein ID: WP_038912335.1
Location: 4991470..4991736 (267 bp)
Type: Antitoxin
Protein ID: WP_033112453.1
Location: 4991736..4993055 (1320 bp)
Type: Toxin
Protein ID: WP_038912333.1
Location: 4986767..4987378 (612 bp)
Type: Others
Protein ID: WP_038912338.1
Location: 4988026..4989111 (1086 bp)
Type: Others
Protein ID: WP_038912337.1
Location: 4993127..4994491 (1365 bp)
Type: Others
Protein ID: WP_038912332.1
Location: 4994607..4996238 (1632 bp)
Type: Others
Protein ID: WP_038912331.1
Location: 4996241..4996498 (258 bp)
Type: Others
Protein ID: WP_013320102.1
Location: 4996462..4996821 (360 bp)
Type: Others
Protein ID: WP_013320101.1
Location: 4996840..4996980 (141 bp)
Type: Others
Protein ID: WP_004093983.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CO076_RS226004986767..4987378-612WP_038912338.1NAD(P)-dependent oxidoreductase-
CO076_RS226054987521..4987901+381WP_038902818.1helix-turn-helix transcriptional regulator-
CO076_RS226104988026..4989111-1086WP_038912337.14-hydroxyphenylpyruvate dioxygenase-
CO076_RS226154989426..4990199+774WP_038912336.1MBL fold metallo-hydrolase-
CO076_RS226204990242..4991198+957WP_038912335.1helix-turn-helix domain-containing protein-
CO076_RS226254991470..4991736+267WP_033112453.1helix-turn-helix domain-containing proteinAntitoxin
CO076_RS226304991736..4993055+1320WP_038912333.1type II toxin-antitoxin system HipA family toxinToxin
CO076_RS226354993127..4994491-1365WP_038912332.1tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE-
CO076_RS226404994607..4996238-1632WP_038912331.1membrane protein insertase YidC-
CO076_RS226454996241..4996498-258WP_013320102.1membrane protein insertion efficiency factor YidD-
CO076_RS226504996462..4996821-360WP_013320101.1ribonuclease P protein component-
CO076_RS226554996840..4996980-141WP_004093983.150S ribosomal protein L34-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49338.50 Da        Isoelectric Point: 7.5719

>T81307 WP_038912333.1 NZ_CP023467:4991736-4993055 [Dickeya dadantii]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGNRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGIPARDIKQIEYKTLSEQQLESILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLNNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIARAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRRDAKLAMGLAGTRGKKYHIEQIFPRHFFQTAKAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSRRLTTGWE

Download         Length: 1320 bp

>T81307 NZ_CP023467:4991736-4993055 [Dickeya dadantii]
ATGGCTGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGGATTCTGACCAAAACGGGCAGTGGCGCACATCATTTTTC
CTACGATGCGAACTGGCTCGGGTTGCCGGGGAACCGACCCATTTCGCTCTCTATGCCACTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGGCGAATTGTTGCCAGGCATCAT
GCGGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTGGTGCCGCAGGG
TATTCCTGCTCGCGATATAAAACAGATTGAATATAAAACCTTATCCGAGCAACAGCTTGAAAGCATACTGTCGGGGTATC
TGTCCGATGCCCCTCTGGGGATGATTGATACAGAAGACGATTTTCGAATCTCTATTGCTGGCGCACAGGAAAAAACGGCC
CTGCTTTATCTGAATAATCACTGGTGCCTGCCCTTCAATACCACACCAACTACCCACATCATCAAACTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAGAATGAGTACCTGTGCCTGCTCATTGCCAGGGCAT
TTGGGCTACCGGTGCCGCACTGTTTTATGATCAAAGCTGGCAAGATAAAAGCTCTGGCCGTGGAGCGTTTTGATCGCAAA
TATGCTTCGGATGGCAGTTGGATTATGCGGCTGCCGCAGGAGGATTTTTGTCAGGTATTAAACGTGCCTTCCGCACTAAA
ATATGAAAATCATGGTGGACCAGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCGGTTGATCCACAAAGGGATCGTT
ATAGTTTTATGAAGGCGCAGGTGCTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCTTGTTTATT
GAGTCTGAGGGAAGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGGGGGCGGGGAATTGA
CCGTAGAGATGCGAAGCTAGCGATGGGGCTGGCTGGCACCAGAGGTAAGAAATACCATATCGAGCAGATATTCCCTCGGC
ATTTTTTCCAAACGGCAAAGGCGGTTGGCTTTGCCAGAGAATCAATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATTCGCGATGCGATCTTGGGAGGGTT
ACAGACTAGATCGAGGCGATTGACGACGGGTTGGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9883.23 Da        Isoelectric Point: 9.7281

>AT81307 WP_033112453.1 NZ_CP023467:4991470-4991736 [Dickeya dadantii]
MKVTNAKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Download         Length: 267 bp

>AT81307 NZ_CP023467:4991470-4991736 [Dickeya dadantii]
ATGAAAGTCACCAACGCCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGACACGGTATCCAGCTTCGAACAACATCCTGATTCCACCAAGCTGGAAACATTCT
TTAAAATCCTGTCGGCATTGAATTTAGAACTTACGGTTACTCCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTC
GCACCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References