Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4991470..4993055 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CO076_RS22630 Protein ID WP_038912333.1
Coordinates 4991736..4993055 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CO076_RS22625 Protein ID WP_033112453.1
Coordinates 4991470..4991736 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO076_RS22600 4986767..4987378 - 612 WP_038912338.1 NAD(P)-dependent oxidoreductase -
CO076_RS22605 4987521..4987901 + 381 WP_038902818.1 helix-turn-helix transcriptional regulator -
CO076_RS22610 4988026..4989111 - 1086 WP_038912337.1 4-hydroxyphenylpyruvate dioxygenase -
CO076_RS22615 4989426..4990199 + 774 WP_038912336.1 MBL fold metallo-hydrolase -
CO076_RS22620 4990242..4991198 + 957 WP_038912335.1 helix-turn-helix domain-containing protein -
CO076_RS22625 4991470..4991736 + 267 WP_033112453.1 helix-turn-helix domain-containing protein Antitoxin
CO076_RS22630 4991736..4993055 + 1320 WP_038912333.1 type II toxin-antitoxin system HipA family toxin Toxin
CO076_RS22635 4993127..4994491 - 1365 WP_038912332.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
CO076_RS22640 4994607..4996238 - 1632 WP_038912331.1 membrane protein insertase YidC -
CO076_RS22645 4996241..4996498 - 258 WP_013320102.1 membrane protein insertion efficiency factor YidD -
CO076_RS22650 4996462..4996821 - 360 WP_013320101.1 ribonuclease P protein component -
CO076_RS22655 4996840..4996980 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49338.50 Da        Isoelectric Point: 7.5719

>T81307 WP_038912333.1 NZ_CP023467:4991736-4993055 [Dickeya dadantii]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGNRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGIPARDIKQIEYKTLSEQQLESILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLNNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIARAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRRDAKLAMGLAGTRGKKYHIEQIFPRHFFQTAKAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSRRLTTGWE

Download         Length: 1320 bp

>T81307 NZ_CP023467:4991736-4993055 [Dickeya dadantii]
ATGGCTGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGGATTCTGACCAAAACGGGCAGTGGCGCACATCATTTTTC
CTACGATGCGAACTGGCTCGGGTTGCCGGGGAACCGACCCATTTCGCTCTCTATGCCACTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGGCGAATTGTTGCCAGGCATCAT
GCGGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTGGTGCCGCAGGG
TATTCCTGCTCGCGATATAAAACAGATTGAATATAAAACCTTATCCGAGCAACAGCTTGAAAGCATACTGTCGGGGTATC
TGTCCGATGCCCCTCTGGGGATGATTGATACAGAAGACGATTTTCGAATCTCTATTGCTGGCGCACAGGAAAAAACGGCC
CTGCTTTATCTGAATAATCACTGGTGCCTGCCCTTCAATACCACACCAACTACCCACATCATCAAACTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAGAATGAGTACCTGTGCCTGCTCATTGCCAGGGCAT
TTGGGCTACCGGTGCCGCACTGTTTTATGATCAAAGCTGGCAAGATAAAAGCTCTGGCCGTGGAGCGTTTTGATCGCAAA
TATGCTTCGGATGGCAGTTGGATTATGCGGCTGCCGCAGGAGGATTTTTGTCAGGTATTAAACGTGCCTTCCGCACTAAA
ATATGAAAATCATGGTGGACCAGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCGGTTGATCCACAAAGGGATCGTT
ATAGTTTTATGAAGGCGCAGGTGCTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCTTGTTTATT
GAGTCTGAGGGAAGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGGGGGCGGGGAATTGA
CCGTAGAGATGCGAAGCTAGCGATGGGGCTGGCTGGCACCAGAGGTAAGAAATACCATATCGAGCAGATATTCCCTCGGC
ATTTTTTCCAAACGGCAAAGGCGGTTGGCTTTGCCAGAGAATCAATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATTCGCGATGCGATCTTGGGAGGGTT
ACAGACTAGATCGAGGCGATTGACGACGGGTTGGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9883.23 Da        Isoelectric Point: 9.7281

>AT81307 WP_033112453.1 NZ_CP023467:4991470-4991736 [Dickeya dadantii]
MKVTNAKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Download         Length: 267 bp

>AT81307 NZ_CP023467:4991470-4991736 [Dickeya dadantii]
ATGAAAGTCACCAACGCCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGACACGGTATCCAGCTTCGAACAACATCCTGATTCCACCAAGCTGGAAACATTCT
TTAAAATCCTGTCGGCATTGAATTTAGAACTTACGGTTACTCCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTC
GCACCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References