Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1893226..1893779 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CO076_RS08585 Protein ID WP_019844797.1
Coordinates 1893465..1893779 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag CO076_RS08580 Protein ID WP_038911535.1
Coordinates 1893226..1893462 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO076_RS08560 1888254..1888844 + 591 WP_038910883.1 hypothetical protein -
CO076_RS08565 1889070..1890773 + 1704 WP_038910884.1 DUF2326 domain-containing protein -
CO076_RS08570 1890913..1892023 - 1111 Protein_1640 IS3 family transposase -
CO076_RS08575 1892103..1892906 + 804 Protein_1641 DUF1738 domain-containing protein -
CO076_RS08580 1893226..1893462 + 237 WP_038911535.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CO076_RS08585 1893465..1893779 + 315 WP_019844797.1 CcdB family protein Toxin
CO076_RS08590 1893776..1894042 - 267 Protein_1644 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
CO076_RS08595 1894044..1896548 + 2505 Protein_1645 DNA/RNA non-specific endonuclease -
CO076_RS08600 1896545..1896955 + 411 WP_081639236.1 RhsIA family immunity protein -
CO076_RS22895 1897303..1897469 + 167 Protein_1647 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1796087..1941535 145448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11486.40 Da        Isoelectric Point: 7.9859

>T81297 WP_019844797.1 NZ_CP023467:1893465-1893779 [Dickeya dadantii]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Download         Length: 315 bp

>T81297 NZ_CP023467:1893465-1893779 [Dickeya dadantii]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTGAATCGTCGGATAGTGATCCCGTTACTCCCTGTTGAAAAATACCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGCATCCCTGTGCAGGCTTTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9047.05 Da        Isoelectric Point: 6.4792

>AT81297 WP_038911535.1 NZ_CP023467:1893226-1893462 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRHHEAKKWQEENRESIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT81297 NZ_CP023467:1893226-1893462 [Dickeya dadantii]
ATGACCGCGAAACAACGTAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTGCTGGTCCGGGCGCGTGAAGCGGG
GATTAACCTGAGTGCCACCCTGACAACCGCCCTGGATGCAGAGCTTCGCCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGAGAATCCATCGACGCATTAAATCGTTTTCATGATGAACACGGCTGTTTCAGCGATGAATACCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References