Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241562..1242187 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag CO076_RS05785 Protein ID WP_009114000.1
Coordinates 1241562..1241765 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0SD88
Locus tag CO076_RS05790 Protein ID WP_013316870.1
Coordinates 1241819..1242187 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO076_RS05755 1237221..1237559 + 339 WP_002208627.1 P-II family nitrogen regulator -
CO076_RS05760 1237602..1238894 + 1293 WP_013316866.1 ammonium transporter AmtB -
CO076_RS05765 1238989..1239852 - 864 WP_038900569.1 acyl-CoA thioesterase II -
CO076_RS05770 1240087..1240644 + 558 WP_038910531.1 YbaY family lipoprotein -
CO076_RS05775 1240675..1241004 - 330 WP_038900571.1 MGMT family protein -
CO076_RS05785 1241562..1241765 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
CO076_RS05790 1241819..1242187 - 369 WP_013316870.1 Hha toxicity modulator TomB Antitoxin
CO076_RS05795 1242695..1242838 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
CO076_RS05800 1242854..1243105 - 252 WP_013316872.1 type B 50S ribosomal protein L31 -
CO076_RS05805 1243285..1246431 - 3147 WP_013316873.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T81295 WP_009114000.1 NZ_CP023467:c1241765-1241562 [Dickeya dadantii]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T81295 NZ_CP023467:c1241765-1241562 [Dickeya dadantii]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAACGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGACGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAAC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT81295 WP_013316870.1 NZ_CP023467:c1242187-1241819 [Dickeya dadantii]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT81295 NZ_CP023467:c1242187-1241819 [Dickeya dadantii]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAAC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTA
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB E0SD88

References