Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 460620..461362 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name ataT Uniprot ID E0SIC1
Locus tag CO076_RS02145 Protein ID WP_013316117.1
Coordinates 460620..461099 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID E0SJ01
Locus tag CO076_RS02150 Protein ID WP_013316118.1
Coordinates 461090..461362 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO076_RS02125 455710..456978 + 1269 WP_038910093.1 integrase arm-type DNA-binding domain-containing protein -
CO076_RS02130 457077..458294 + 1218 WP_038910094.1 dNTP triphosphohydrolase -
CO076_RS02135 458338..459966 + 1629 WP_038910095.1 TIGR04141 family sporadically distributed protein -
CO076_RS02140 460190..460591 - 402 WP_038910096.1 hypothetical protein -
CO076_RS02145 460620..461099 - 480 WP_013316117.1 GNAT family N-acetyltransferase Toxin
CO076_RS02150 461090..461362 - 273 WP_013316118.1 DUF1778 domain-containing protein Antitoxin
CO076_RS02160 461852..462310 + 459 Protein_406 integrase family protein -
CO076_RS02165 462337..463194 + 858 WP_038910100.1 hypothetical protein -
CO076_RS02170 463768..465942 + 2175 WP_159077855.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-147)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17564.34 Da        Isoelectric Point: 9.5367

>T81292 WP_013316117.1 NZ_CP023467:c461099-460620 [Dickeya dadantii]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW

Download         Length: 480 bp

>T81292 NZ_CP023467:c461099-460620 [Dickeya dadantii]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCAGTTGTGGATTTTCATTGTTCCGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCACCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGTATGGGGATCGGTGCCGGGCTTCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10384.88 Da        Isoelectric Point: 4.6702

>AT81292 WP_013316118.1 NZ_CP023467:c461362-461090 [Dickeya dadantii]
MRTEPKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE

Download         Length: 273 bp

>AT81292 NZ_CP023467:c461362-461090 [Dickeya dadantii]
ATGCGAACAGAGCCAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCCGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAAAGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGTTGGAATCACCAGTCACAGATAATCCGCGTGTGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N0G158

Antitoxin

Source ID Structure
AlphaFold DB E0SJ01

References