Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3188147..3188717 Replicon chromosome
Accession NZ_CP023449
Organism Rhizorhabdus dicambivorans strain Ndbn-20

Toxin (Protein)


Gene name relE Uniprot ID A0A2A4FU08
Locus tag CMV14_RS15030 Protein ID WP_066962939.1
Coordinates 3188147..3188431 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A4FW23
Locus tag CMV14_RS15035 Protein ID WP_066962942.1
Coordinates 3188412..3188717 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CMV14_RS15020 3186881..3187396 - 516 Protein_2982 DNA polymerase Y family protein -
CMV14_RS15025 3187326..3188087 - 762 Protein_2983 hypothetical protein -
CMV14_RS15030 3188147..3188431 - 285 WP_066962939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CMV14_RS15035 3188412..3188717 - 306 WP_066962942.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CMV14_RS15040 3188763..3189638 - 876 WP_066962945.1 LysR family transcriptional regulator -
CMV14_RS15045 3189748..3190677 + 930 WP_066962948.1 subclass B3 metallo-beta-lactamase -
CMV14_RS15050 3190845..3191591 - 747 WP_066962956.1 DNA-binding domain-containing protein -
CMV14_RS15055 3191588..3192433 - 846 WP_066962958.1 DUF692 domain-containing protein -
CMV14_RS15060 3192497..3192766 - 270 WP_066962962.1 hypothetical protein -
CMV14_RS15065 3192869..3193510 - 642 WP_066962967.1 DUF1109 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-50)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10540.12 Da        Isoelectric Point: 5.8352

>T81282 WP_066962939.1 NZ_CP023449:c3188431-3188147 [Rhizorhabdus dicambivorans]
VAKSRLEWREAARADLLAIVDYISDDNPDAALALLDDVEAKATQLVDNPKMYQAGRVAGTREMLVRKSYIVVYAEDARAV
TILRVLHAAQMWPR

Download         Length: 285 bp

>T81282 NZ_CP023449:c3188431-3188147 [Rhizorhabdus dicambivorans]
GTGGCCAAATCAAGGCTTGAATGGCGGGAGGCGGCGCGCGCCGACCTGCTGGCGATCGTCGACTATATCTCGGATGACAA
TCCGGACGCTGCGCTCGCCCTGCTCGATGACGTCGAGGCCAAGGCTACCCAACTCGTCGATAATCCAAAAATGTATCAGG
CTGGCCGGGTCGCAGGCACCCGCGAGATGCTGGTCCGGAAAAGCTACATTGTCGTCTATGCCGAAGACGCACGGGCCGTG
ACGATTTTGCGGGTGCTGCACGCCGCGCAGATGTGGCCGCGCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11036.70 Da        Isoelectric Point: 8.8444

>AT81282 WP_066962942.1 NZ_CP023449:c3188717-3188412 [Rhizorhabdus dicambivorans]
MGAQTSMLHVRVDETLKAQASETLANVGLTVSDAVRILLTRIVKEGGLPAGLVADPVAHDAWFRAKVREALDDTNPPVEH
DRVMADTRALIERKRRGQIKA

Download         Length: 306 bp

>AT81282 NZ_CP023449:c3188717-3188412 [Rhizorhabdus dicambivorans]
ATGGGCGCCCAGACCTCGATGCTCCACGTCCGGGTGGATGAAACCCTCAAGGCACAGGCTTCGGAAACGCTCGCCAATGT
CGGGCTTACCGTGTCCGATGCGGTCCGGATATTGTTGACGCGCATTGTGAAGGAGGGCGGGCTTCCCGCTGGCTTGGTCG
CCGATCCCGTTGCGCATGATGCCTGGTTCCGCGCGAAGGTGCGGGAGGCGCTCGACGACACCAACCCGCCTGTCGAGCAT
GACCGGGTCATGGCGGATACCCGCGCCTTGATCGAGCGGAAGCGGCGTGGCCAAATCAAGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4FU08

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4FW23

References