Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 71985..72637 Replicon plasmid pTX1
Accession NZ_CP023440
Organism Thauera sp. K11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCZ27_RS22835 Protein ID WP_096453040.1
Coordinates 72221..72637 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CCZ27_RS22830 Protein ID WP_096453148.1
Coordinates 71985..72221 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS22795 67952..68620 - 669 WP_096453031.1 SOS response-associated peptidase -
CCZ27_RS22800 68709..69041 + 333 WP_096453033.1 hypothetical protein -
CCZ27_RS22805 69045..69266 - 222 Protein_70 hypothetical protein -
CCZ27_RS22815 70094..70237 - 144 WP_198363388.1 hypothetical protein -
CCZ27_RS22820 70452..70946 + 495 WP_096453037.1 H-NS histone family protein -
CCZ27_RS22825 71171..71719 - 549 WP_096453038.1 TIGR02281 family clan AA aspartic protease -
CCZ27_RS22830 71985..72221 + 237 WP_096453148.1 AbrB family transcriptional regulator Antitoxin
CCZ27_RS22835 72221..72637 + 417 WP_096453040.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ27_RS22840 73120..73737 + 618 WP_096453042.1 DNA-binding protein -
CCZ27_RS22845 73968..74363 - 396 WP_096453044.1 type II toxin-antitoxin system VapC family toxin -
CCZ27_RS22850 74360..74611 - 252 WP_096453046.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..140963 140963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15123.38 Da        Isoelectric Point: 4.7452

>T81277 WP_096453040.1 NZ_CP023440:72221-72637 [Thauera sp. K11]
MARYMLDTNMCIYLMKNQPEAVARRFAQCYVGDVVMSAITYAELEYGVAVCADPEREKANLAALIEDIPVVAFDAAAGVA
YGPIRLATRENKKDALDKLIAAHAVSIGVTVVTNNTKDFVRYPGVAVENWLEPEKDGH

Download         Length: 417 bp

>T81277 NZ_CP023440:72221-72637 [Thauera sp. K11]
ATGGCGCGCTACATGCTCGACACGAACATGTGCATCTACCTGATGAAAAACCAGCCCGAGGCGGTCGCCCGGCGCTTCGC
ACAGTGCTACGTCGGTGACGTGGTCATGTCAGCGATCACCTACGCCGAACTGGAGTACGGCGTAGCTGTGTGTGCGGATC
CAGAGCGGGAAAAGGCCAATCTGGCAGCGCTTATTGAGGATATTCCCGTCGTTGCGTTCGATGCAGCGGCGGGAGTAGCG
TACGGACCGATCCGGCTTGCAACCCGCGAGAACAAGAAGGATGCGCTCGACAAGCTGATCGCCGCTCACGCGGTCTCCAT
CGGCGTGACGGTCGTGACCAACAACACCAAGGACTTTGTCAGGTATCCCGGCGTAGCGGTTGAGAACTGGCTGGAGCCCG
AAAAGGATGGTCACTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8949.95 Da        Isoelectric Point: 5.1651

>AT81277 WP_096453148.1 NZ_CP023440:71985-72221 [Thauera sp. K11]
MHTTRAFKNGNSQAVRIPADLAYDRTDIELEIEREGDEIRIRPARRSLSGVLSKFAKFAPEFMEQGRGDQEQNERDAL

Download         Length: 237 bp

>AT81277 NZ_CP023440:71985-72221 [Thauera sp. K11]
ATGCACACGACACGCGCGTTCAAGAACGGCAACTCACAAGCCGTCCGCATCCCCGCCGACCTGGCTTACGACAGAACGGA
CATCGAGCTTGAGATCGAACGGGAAGGTGACGAGATCCGCATCCGTCCGGCGCGTCGATCGCTTTCGGGGGTGCTCTCGA
AATTCGCCAAATTCGCCCCGGAGTTCATGGAACAAGGTCGTGGCGACCAGGAGCAAAATGAAAGGGACGCACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References