Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 29518..30071 Replicon plasmid pTX1
Accession NZ_CP023440
Organism Thauera sp. K11

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CCZ27_RS22620 Protein ID WP_096452975.1
Coordinates 29778..30071 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CCZ27_RS22615 Protein ID WP_096452973.1
Coordinates 29518..29790 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS22590 24684..25121 + 438 WP_096452963.1 conjugal transfer protein TraM -
CCZ27_RS22595 25569..25922 - 354 WP_096452965.1 conjugal transfer protein TraO -
CCZ27_RS22600 26316..26885 - 570 WP_096452967.1 DNA repair protein RadC -
CCZ27_RS22605 27681..28217 + 537 WP_096452969.1 phasin family protein -
CCZ27_RS22610 28355..28645 - 291 WP_157748692.1 hypothetical protein -
CCZ27_RS23825 29005..29433 + 429 WP_157748693.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
CCZ27_RS22615 29518..29790 + 273 WP_096452973.1 CopG family ribbon-helix-helix protein Antitoxin
CCZ27_RS22620 29778..30071 + 294 WP_096452975.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCZ27_RS22625 30177..31784 + 1608 WP_096452977.1 type I restriction-modification system subunit M -
CCZ27_RS23830 31781..32056 + 276 WP_157748694.1 hypothetical protein -
CCZ27_RS22630 32185..32937 - 753 WP_096452979.1 IS21-like element helper ATPase IstB -
CCZ27_RS22635 32934..34475 - 1542 WP_096452981.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..140963 140963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10774.33 Da        Isoelectric Point: 6.2244

>T81276 WP_096452975.1 NZ_CP023440:29778-30071 [Thauera sp. K11]
VPHVIVTAGAAEGLERCREFLATKAPEAARRAGQAIERQLRLLETAPDIGRPFPDMPELRELVIAFGDSGYLALYRHEPT
VDAVYVLAFRHQKEAGY

Download         Length: 294 bp

>T81276 NZ_CP023440:29778-30071 [Thauera sp. K11]
GTGCCACACGTAATCGTTACCGCAGGCGCAGCGGAAGGCTTGGAGCGATGCCGCGAGTTCCTGGCCACCAAAGCACCTGA
AGCCGCTCGGCGGGCGGGTCAGGCGATCGAGCGGCAATTGCGGCTGCTGGAAACAGCTCCCGACATTGGCAGACCGTTTC
CTGACATGCCTGAACTGCGCGAGTTAGTGATTGCCTTCGGGGACTCCGGCTATCTCGCACTGTATCGGCATGAACCGACC
GTTGATGCGGTGTATGTCTTGGCATTCCGGCATCAGAAAGAGGCCGGGTACTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10442.67 Da        Isoelectric Point: 6.2220

>AT81276 WP_096452973.1 NZ_CP023440:29518-29790 [Thauera sp. K11]
MATSLKIDDALKGRVQQLAGQRRRSAHWIMLEAIQQYVEREEARERFKQEALASWVAYQETGQHLTGQEVRTWLNTWGTE
DETTVPACHT

Download         Length: 273 bp

>AT81276 NZ_CP023440:29518-29790 [Thauera sp. K11]
ATGGCAACCTCGCTCAAGATTGACGACGCGTTGAAAGGTCGCGTCCAGCAACTCGCCGGTCAGCGCCGCCGCTCGGCACA
CTGGATCATGCTTGAAGCGATCCAGCAGTACGTCGAGCGTGAGGAAGCCCGTGAACGCTTCAAACAGGAAGCCTTGGCAT
CGTGGGTGGCCTATCAAGAAACAGGCCAGCACCTGACAGGGCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCGAA
GACGAGACGACGGTGCCTGCGTGCCACACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References