Detailed information of TA system TA081274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4412316..4412953
• Replicon: chromosome
• Accession: NZ_CP023439
• Organism: Thauera sp. K11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCZ27_RS19420
• Protein ID: WP_096450941.1
• Coordinates: 4412316..4412723 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: CCZ27_RS19425
• Protein ID: WP_096450943.1
• Coordinates: 4412723..4412953 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCZ27_RS19395	4407500..4408252	-	753	WP_096450931.1	5-oxoprolinase subunit PxpB	-
CCZ27_RS19400	4408262..4409017	-	756	WP_096450933.1	DUF2135 domain-containing protein	-
CCZ27_RS19405	4408995..4409867	-	873	WP_096450935.1	DUF2135 domain-containing protein	-
CCZ27_RS19410	4410001..4411677	-	1677	WP_157748640.1	DUF2300 domain-containing protein	-
CCZ27_RS19415	4411704..4412261	-	558	WP_096450939.1	mechanosensitive ion channel family protein	-
CCZ27_RS19420	4412316..4412723	-	408	WP_096450941.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCZ27_RS19425	4412723..4412953	-	231	WP_096450943.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CCZ27_RS19430	4413011..4417642	-	4632	WP_198363191.1	alpha-2-macroglobulin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4209727..4556793	347066

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15029.12 Da
• Isoelectric Point: 6.8730

>T81274 WP_096450941.1 NZ_CP023439:c4412723-4412316 [Thauera sp. K11]
MAVRYLLDTNICIYIAKHNPPAVRERFARHAADELVMSVVTLGELLFGAEKSQARERALETIARLNSVIRVADLPEAAGV
HYGQIRAALQKGGQPIGNNDLWLAAHARAEGWTLVTNDEREFRRVEGLQVENWAA

Nucleotide

• Length: 408 bp

>T81274 NZ_CP023439:c4412723-4412316 [Thauera sp. K11]
ATGGCCGTGCGCTATCTGCTCGACACCAACATCTGTATCTACATCGCCAAGCACAATCCGCCTGCCGTGCGCGAACGTTT
CGCGCGCCACGCTGCCGATGAACTGGTGATGTCGGTCGTCACCCTGGGCGAACTGCTGTTCGGCGCCGAGAAGAGCCAGG
CGCGGGAGCGGGCCCTGGAGACGATCGCACGCCTGAACTCGGTGATCCGGGTGGCGGACCTTCCCGAGGCCGCAGGGGTG
CATTACGGGCAGATTCGCGCTGCGTTGCAGAAAGGCGGCCAGCCGATCGGCAACAACGATCTCTGGCTCGCTGCCCATGC
CCGCGCCGAAGGCTGGACACTCGTGACCAACGACGAGCGCGAGTTCCGCCGCGTCGAAGGATTGCAGGTGGAGAACTGGG
CCGCCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8520.59 Da
• Isoelectric Point: 4.7719

>AT81274 WP_096450943.1 NZ_CP023439:c4412953-4412723 [Thauera sp. K11]
MAYARIFRSGNSQAVRLPKEFRFDVDQVEIFRRGDEVVLRPRPASAAAIFDALAGLPGDFLAEGREDTPPQERESL

Nucleotide

• Length: 231 bp

>AT81274 NZ_CP023439:c4412953-4412723 [Thauera sp. K11]
ATGGCTTATGCCCGCATCTTCCGTTCCGGTAACAGCCAGGCCGTCCGCCTGCCCAAGGAATTCCGTTTCGACGTGGACCA
GGTGGAGATTTTCCGCCGTGGCGACGAGGTGGTCCTGCGGCCAAGGCCGGCCAGCGCCGCGGCCATCTTCGACGCCCTTG
CCGGCCTGCCCGGCGATTTCCTCGCCGAAGGCCGCGAGGACACGCCGCCGCAGGAGCGGGAGAGCCTGTGA