Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4412316..4412953 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCZ27_RS19420 Protein ID WP_096450941.1
Coordinates 4412316..4412723 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag CCZ27_RS19425 Protein ID WP_096450943.1
Coordinates 4412723..4412953 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS19395 4407500..4408252 - 753 WP_096450931.1 5-oxoprolinase subunit PxpB -
CCZ27_RS19400 4408262..4409017 - 756 WP_096450933.1 DUF2135 domain-containing protein -
CCZ27_RS19405 4408995..4409867 - 873 WP_096450935.1 DUF2135 domain-containing protein -
CCZ27_RS19410 4410001..4411677 - 1677 WP_157748640.1 DUF2300 domain-containing protein -
CCZ27_RS19415 4411704..4412261 - 558 WP_096450939.1 mechanosensitive ion channel family protein -
CCZ27_RS19420 4412316..4412723 - 408 WP_096450941.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ27_RS19425 4412723..4412953 - 231 WP_096450943.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CCZ27_RS19430 4413011..4417642 - 4632 WP_198363191.1 alpha-2-macroglobulin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4209727..4556793 347066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15029.12 Da        Isoelectric Point: 6.8730

>T81274 WP_096450941.1 NZ_CP023439:c4412723-4412316 [Thauera sp. K11]
MAVRYLLDTNICIYIAKHNPPAVRERFARHAADELVMSVVTLGELLFGAEKSQARERALETIARLNSVIRVADLPEAAGV
HYGQIRAALQKGGQPIGNNDLWLAAHARAEGWTLVTNDEREFRRVEGLQVENWAA

Download         Length: 408 bp

>T81274 NZ_CP023439:c4412723-4412316 [Thauera sp. K11]
ATGGCCGTGCGCTATCTGCTCGACACCAACATCTGTATCTACATCGCCAAGCACAATCCGCCTGCCGTGCGCGAACGTTT
CGCGCGCCACGCTGCCGATGAACTGGTGATGTCGGTCGTCACCCTGGGCGAACTGCTGTTCGGCGCCGAGAAGAGCCAGG
CGCGGGAGCGGGCCCTGGAGACGATCGCACGCCTGAACTCGGTGATCCGGGTGGCGGACCTTCCCGAGGCCGCAGGGGTG
CATTACGGGCAGATTCGCGCTGCGTTGCAGAAAGGCGGCCAGCCGATCGGCAACAACGATCTCTGGCTCGCTGCCCATGC
CCGCGCCGAAGGCTGGACACTCGTGACCAACGACGAGCGCGAGTTCCGCCGCGTCGAAGGATTGCAGGTGGAGAACTGGG
CCGCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8520.59 Da        Isoelectric Point: 4.7719

>AT81274 WP_096450943.1 NZ_CP023439:c4412953-4412723 [Thauera sp. K11]
MAYARIFRSGNSQAVRLPKEFRFDVDQVEIFRRGDEVVLRPRPASAAAIFDALAGLPGDFLAEGREDTPPQERESL

Download         Length: 231 bp

>AT81274 NZ_CP023439:c4412953-4412723 [Thauera sp. K11]
ATGGCTTATGCCCGCATCTTCCGTTCCGGTAACAGCCAGGCCGTCCGCCTGCCCAAGGAATTCCGTTTCGACGTGGACCA
GGTGGAGATTTTCCGCCGTGGCGACGAGGTGGTCCTGCGGCCAAGGCCGGCCAGCGCCGCGGCCATCTTCGACGCCCTTG
CCGGCCTGCCCGGCGATTTCCTCGCCGAAGGCCGCGAGGACACGCCGCCGCAGGAGCGGGAGAGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References