Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2924224..2925014 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag CCZ27_RS12625 Protein ID WP_096448660.1
Coordinates 2924511..2925014 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag CCZ27_RS12620 Protein ID WP_096448658.1
Coordinates 2924224..2924514 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS12600 2919663..2920757 + 1095 WP_096448650.1 substrate-binding domain-containing protein -
CCZ27_RS12605 2920768..2921946 + 1179 WP_096448652.1 toxic anion resistance protein -
CCZ27_RS12610 2921933..2923537 + 1605 WP_096448654.1 VWA domain-containing protein -
CCZ27_RS12615 2923534..2924157 + 624 WP_096448656.1 hypothetical protein -
CCZ27_RS12620 2924224..2924514 + 291 WP_096448658.1 DUF1778 domain-containing protein Antitoxin
CCZ27_RS12625 2924511..2925014 + 504 WP_096448660.1 GNAT family N-acetyltransferase Toxin
CCZ27_RS12630 2925622..2928501 + 2880 WP_096452513.1 adenosylcobalamin-dependent ribonucleoside-diphosphate reductase -
CCZ27_RS12635 2928544..2929350 + 807 WP_096448662.1 sel1 repeat family protein -
CCZ27_RS12640 2929455..2929919 - 465 WP_096448664.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18087.90 Da        Isoelectric Point: 9.0099

>T81273 WP_096448660.1 NZ_CP023439:2924511-2925014 [Thauera sp. K11]
MTVRAPEPLDSHHELETFSSGVESLDHWLKRRALKNQATGASRTFVACVDRRVLAYYALASSAIIADAAPGRFRRNMPDP
IPVVVLGRLAVDLSLQGRGMGRALMRDAGLRVIQAADTIGIRGMIVHALSAEAKAFYEQIGFESSPLDPMTLMVTLTDLR
SSLAPSA

Download         Length: 504 bp

>T81273 NZ_CP023439:2924511-2925014 [Thauera sp. K11]
ATGACGGTTCGCGCGCCGGAGCCGTTGGACTCTCATCACGAGCTTGAAACGTTCTCGTCGGGCGTCGAGAGTCTCGACCA
TTGGCTGAAACGTCGCGCCCTGAAGAATCAGGCGACTGGTGCATCCCGCACTTTCGTTGCGTGCGTGGATCGCCGCGTAC
TGGCGTACTACGCCCTCGCTTCGAGCGCGATTATCGCAGACGCCGCACCGGGCCGTTTTCGCCGCAACATGCCAGACCCG
ATTCCCGTCGTGGTCCTTGGACGACTGGCCGTAGACCTTTCACTGCAGGGAAGAGGTATGGGCCGTGCCTTGATGCGGGA
TGCCGGACTACGCGTCATCCAGGCTGCGGATACCATCGGAATCCGCGGGATGATCGTGCACGCGCTCTCCGCCGAGGCAA
AAGCTTTTTATGAGCAGATCGGCTTCGAGTCATCACCGCTGGATCCGATGACGCTGATGGTCACACTGACCGACTTGAGA
TCGAGCTTGGCCCCTTCGGCGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10786.26 Da        Isoelectric Point: 6.3844

>AT81273 WP_096448658.1 NZ_CP023439:2924224-2924514 [Thauera sp. K11]
MATPNTERGARETLNIRIKPDERSLIDRAAKARGKNRSEFVLEAARIAAEEALLDQVIISASPEAYEAFLARLDMPPQPN
ERLRKTMQTPAPWENA

Download         Length: 291 bp

>AT81273 NZ_CP023439:2924224-2924514 [Thauera sp. K11]
ATGGCGACACCAAACACCGAACGCGGCGCACGCGAAACGCTGAATATCCGCATCAAACCCGATGAGCGGAGTCTGATAGA
CCGCGCCGCGAAGGCGCGAGGGAAGAATCGCAGCGAGTTCGTGCTGGAAGCCGCACGAATTGCTGCCGAGGAAGCTCTGC
TCGACCAGGTCATCATTTCGGCCAGCCCGGAAGCCTATGAGGCATTCTTGGCGCGGCTCGATATGCCTCCTCAGCCCAAC
GAGCGTCTGCGCAAGACGATGCAGACCCCGGCGCCTTGGGAGAATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References