Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2137635..2138305 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCZ27_RS09255 Protein ID WP_096447553.1
Coordinates 2137635..2138051 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CCZ27_RS09260 Protein ID WP_198363350.1
Coordinates 2138048..2138305 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS09240 2133328..2133921 + 594 WP_096447547.1 potassium-transporting ATPase subunit KdpC -
CCZ27_RS09245 2133944..2136634 + 2691 WP_096447549.1 DUF4118 domain-containing protein -
CCZ27_RS09250 2136627..2137343 + 717 WP_096447551.1 response regulator -
CCZ27_RS09255 2137635..2138051 - 417 WP_096447553.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ27_RS09260 2138048..2138305 - 258 WP_198363350.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CCZ27_RS09265 2138461..2139915 - 1455 WP_096447557.1 DNA-3-methyladenine glycosylase 2 -
CCZ27_RS09270 2140213..2141490 + 1278 WP_096447559.1 MFS transporter -
CCZ27_RS09275 2141609..2142145 - 537 WP_096452367.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14791.19 Da        Isoelectric Point: 7.3582

>T81272 WP_096447553.1 NZ_CP023439:c2138051-2137635 [Thauera sp. K11]
MTIYMLDTNIASHVIKGDIPLVLQRLAAVPMTSVAVSVVTEAELRYGVAKRGNPQGLATRVHEFLIRVEVLAWTQDVARA
YGDLRASCEGAGVTLAPMDMMIAAHAKAAGAILVTRDGAFSRVPHGLQLENWAREAAP

Download         Length: 417 bp

>T81272 NZ_CP023439:c2138051-2137635 [Thauera sp. K11]
ATGACGATTTACATGCTCGACACGAACATCGCGAGTCACGTCATCAAGGGCGACATCCCGCTTGTCTTGCAGCGGCTCGC
GGCCGTGCCCATGACGAGCGTCGCGGTGTCCGTCGTCACTGAGGCCGAGCTTCGGTACGGCGTGGCGAAGCGCGGGAACC
CGCAGGGCCTCGCGACGCGCGTGCATGAATTCCTGATCCGCGTCGAGGTGCTGGCATGGACGCAGGACGTCGCGCGTGCC
TATGGCGATCTGCGCGCCTCTTGCGAAGGCGCCGGCGTGACGCTCGCACCCATGGACATGATGATCGCGGCGCACGCCAA
GGCCGCCGGCGCGATCCTGGTAACGAGGGATGGGGCCTTCAGCCGCGTTCCCCACGGTTTGCAACTGGAGAATTGGGCAA
GAGAGGCTGCACCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9791.87 Da        Isoelectric Point: 4.4819

>AT81272 WP_198363350.1 NZ_CP023439:c2138305-2138048 [Thauera sp. K11]
MQTAKVFTTGRSQAVRLPLEFRFEEKEVYIRRDPVTGDVILSRRPASWDGFFALYQTTEVPADFMSETDRNQGEQTRDPF
EGAAE

Download         Length: 258 bp

>AT81272 NZ_CP023439:c2138305-2138048 [Thauera sp. K11]
ATGCAGACAGCCAAGGTCTTCACCACCGGACGCAGCCAGGCGGTGCGCCTGCCGCTCGAATTCCGGTTTGAGGAAAAGGA
AGTGTATATCCGCCGCGACCCGGTCACCGGCGACGTGATCCTGTCGCGGCGGCCGGCTTCGTGGGACGGCTTTTTCGCGC
TCTACCAGACGACCGAGGTTCCGGCCGACTTCATGAGCGAGACCGATCGCAACCAGGGCGAACAGACCCGCGACCCCTTC
GAGGGCGCCGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References