Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 2082823..2083400 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CCZ27_RS09100 Protein ID WP_096447497.1
Coordinates 2082823..2083113 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag CCZ27_RS09105 Protein ID WP_096447499.1
Coordinates 2083110..2083400 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS09090 2081977..2082324 + 348 WP_096447493.1 type II toxin-antitoxin system RelE/ParE family toxin -
CCZ27_RS09095 2082321..2082653 + 333 WP_096447495.1 helix-turn-helix domain-containing protein -
CCZ27_RS09100 2082823..2083113 - 291 WP_096447497.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCZ27_RS09105 2083110..2083400 - 291 WP_096447499.1 ribbon-helix-helix protein, CopG family Antitoxin
CCZ27_RS09110 2083487..2084221 + 735 WP_096447501.1 type I secretion C-terminal target domain-containing protein -
CCZ27_RS09115 2084461..2084730 + 270 WP_096447503.1 type II toxin-antitoxin system ParD family antitoxin -
CCZ27_RS23475 2084727..2084813 + 87 Protein_1815 type II toxin-antitoxin system RelE/ParE family toxin -
CCZ27_RS09120 2084895..2085179 - 285 WP_096447505.1 type II toxin-antitoxin system RelE/ParE family toxin -
CCZ27_RS09125 2085176..2085454 - 279 WP_096452363.1 antitoxin of toxin-antitoxin stability system -
CCZ27_RS09130 2085711..2085992 - 282 WP_096447507.1 type II toxin-antitoxin system YafQ family toxin -
CCZ27_RS09135 2085979..2086242 - 264 WP_096447509.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CCZ27_RS09145 2086610..2086804 + 195 WP_096447511.1 type II toxin-antitoxin system VapB family antitoxin -
CCZ27_RS09150 2086801..2087214 + 414 WP_096447513.1 PIN domain nuclease -
CCZ27_RS09155 2087255..2088007 - 753 WP_096447515.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2042238..2097107 54869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-89)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 10771.45 Da        Isoelectric Point: 10.7271

>T81270 WP_096447497.1 NZ_CP023439:c2083113-2082823 [Thauera sp. K11]
VKLVWTRPAQEDRKAIRKYIAVDNPSAALDLDELLSASAARLIDHPGLGRPGRVQGTRELVAHRNYILIYDVSGDLVRVL
RVLHAARMWPPTRSAH

Download         Length: 291 bp

>T81270 NZ_CP023439:c2083113-2082823 [Thauera sp. K11]
GTGAAGCTGGTTTGGACCCGGCCGGCACAGGAAGATCGAAAGGCCATCCGCAAATACATCGCAGTTGATAATCCGAGTGC
AGCGCTCGATCTCGATGAACTCCTGTCAGCAAGCGCTGCACGCCTGATCGATCATCCTGGCCTTGGCCGGCCTGGCCGCG
TTCAAGGCACGCGCGAGCTTGTCGCGCATCGCAACTACATCCTCATTTACGATGTCAGCGGCGACTTGGTGCGCGTGCTT
CGTGTCTTGCATGCGGCCCGTATGTGGCCGCCGACCAGATCAGCGCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10823.88 Da        Isoelectric Point: 4.5967

>AT81270 WP_096447499.1 NZ_CP023439:c2083400-2083110 [Thauera sp. K11]
MSETTFTFRVDDDLKEQFTAAAKGRDRSGAQLLRDFMREFVKQQQEADAHDPWFRREVQIGIDAANAGDVVSAEEVEAEA
AAWRSETRRKMAGANS

Download         Length: 291 bp

>AT81270 NZ_CP023439:c2083400-2083110 [Thauera sp. K11]
ATGAGCGAAACAACGTTCACCTTCCGGGTCGATGACGACCTGAAAGAGCAATTCACAGCGGCAGCAAAGGGGCGCGATCG
CAGCGGTGCGCAACTCCTGCGCGATTTCATGCGCGAGTTCGTGAAGCAGCAACAAGAGGCCGACGCTCACGATCCCTGGT
TTCGCCGTGAGGTACAAATCGGCATTGACGCAGCCAATGCCGGAGATGTGGTCTCGGCCGAAGAGGTAGAAGCCGAAGCG
GCGGCCTGGCGGTCGGAGACGCGGCGAAAGATGGCCGGCGCTAATTCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References