Detailed information of TA system TA081269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2058270..2058753
• Replicon: chromosome
• Accession: NZ_CP023439
• Organism: Thauera sp. K11

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: CCZ27_RS08985
• Protein ID: WP_096447457.1
• Coordinates: 2058270..2058542 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CCZ27_RS08990
• Protein ID: WP_096447459.1
• Coordinates: 2058526..2058753 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCZ27_RS08970	2053990..2054975	+	986	Protein_1785	IS5 family transposase	-
CCZ27_RS08975	2055489..2057189	+	1701	WP_096447453.1	IS1634 family transposase	-
CCZ27_RS08980	2057298..2057900	-	603	WP_198363300.1	transposase	-
CCZ27_RS08985	2058270..2058542	-	273	WP_096447457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCZ27_RS08990	2058526..2058753	-	228	WP_096447459.1	ribbon-helix-helix protein, CopG family	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2042238..2097107	54869
	-	flank	IS/Tn	-	-	2055489..2057189	1700

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10577.27 Da
• Isoelectric Point: 10.0930

>T81269 WP_096447457.1 NZ_CP023439:c2058542-2058270 [Thauera sp. K11]
MAWLIKFDEGAEKDLAQLDKQVARRITSFLRERVAVLDDPRSIGEALKGSRLGEFWKYRVGDCRIIASIEDWELRILVVK
VGNRREVYRR

Nucleotide

• Length: 273 bp

>T81269 NZ_CP023439:c2058542-2058270 [Thauera sp. K11]
TTGGCTTGGCTGATTAAGTTCGACGAAGGCGCCGAGAAGGATCTAGCGCAGCTCGACAAACAGGTCGCTAGGCGCATTAC
TTCGTTCCTGCGCGAGCGCGTGGCGGTACTTGACGATCCTCGCAGTATCGGCGAAGCACTCAAGGGTTCGCGCCTCGGTG
AATTCTGGAAGTACCGCGTGGGCGACTGTCGCATCATCGCGAGCATTGAGGACTGGGAGCTTCGCATCTTGGTCGTGAAG
GTCGGAAACCGTCGTGAGGTGTACAGGCGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8413.55 Da
• Isoelectric Point: 4.7778

>AT81269 WP_096447459.1 NZ_CP023439:c2058753-2058526 [Thauera sp. K11]
MATSIRLDPAIEQRLDHLAAATGRTKAFYLRELIANGLDDLEDLYLAEQRLIDVRAGKSKTYTLDEVEKHLGLAD

Nucleotide

• Length: 228 bp

>AT81269 NZ_CP023439:c2058753-2058526 [Thauera sp. K11]
ATGGCAACTTCGATTCGACTCGATCCTGCAATTGAGCAACGGCTCGACCACTTGGCGGCGGCCACTGGTCGCACCAAGGC
GTTCTATCTGCGCGAACTGATTGCGAACGGCCTTGACGATCTTGAAGACCTGTACCTGGCCGAGCAGCGGCTGATCGACG
TTCGCGCAGGCAAGTCCAAGACTTACACGCTGGATGAAGTGGAAAAACACCTTGGCTTGGCTGATTAA