Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1238260..1238930 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCZ27_RS05480 Protein ID WP_096446284.1
Coordinates 1238511..1238930 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CCZ27_RS05475 Protein ID WP_096446282.1
Coordinates 1238260..1238514 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS05455 1233792..1234589 + 798 WP_096446274.1 ABC transporter ATP-binding protein -
CCZ27_RS05460 1234654..1235535 + 882 WP_096446276.1 branched-chain amino acid ABC transporter permease -
CCZ27_RS05465 1235550..1236617 + 1068 WP_096446278.1 branched-chain amino acid ABC transporter permease -
CCZ27_RS05470 1236712..1238040 + 1329 WP_096446280.1 ABC transporter substrate-binding protein -
CCZ27_RS05475 1238260..1238514 + 255 WP_096446282.1 Arc family DNA-binding protein Antitoxin
CCZ27_RS05480 1238511..1238930 + 420 WP_096446284.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ27_RS05485 1239264..1240505 + 1242 WP_096446286.1 acyl-CoA dehydrogenase family protein -
CCZ27_RS05490 1240540..1241799 + 1260 WP_096446288.1 SfnB family sulfur acquisition oxidoreductase -
CCZ27_RS05495 1241834..1243252 + 1419 WP_096446290.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14457.73 Da        Isoelectric Point: 5.8348

>T81268 WP_096446284.1 NZ_CP023439:1238511-1238930 [Thauera sp. K11]
MILLDTNVVSEPLRRAPDARVVEWIDAQPLETLYLSAVTVAELRAGVALLPAGKRRAGLHESLEKQVLPLFAGRLLAFDS
ACTQAYAALMAKARAAGLAIATADGYIAAIAAANGFSVATRDASPFEAAGVAVINPWAA

Download         Length: 420 bp

>T81268 NZ_CP023439:1238511-1238930 [Thauera sp. K11]
ATGATCCTGCTCGACACGAACGTGGTCTCGGAGCCCCTGCGCCGTGCTCCGGACGCCCGCGTGGTCGAGTGGATCGACGC
GCAGCCGCTCGAAACGCTATACCTGTCCGCCGTCACGGTGGCCGAACTGCGCGCCGGCGTGGCGCTGCTGCCGGCCGGCA
AGCGGCGGGCCGGTTTGCATGAGAGCCTGGAAAAGCAGGTGTTGCCGCTGTTCGCCGGGCGCCTGCTGGCTTTCGATTCC
GCATGTACGCAAGCCTATGCGGCGCTGATGGCGAAGGCTCGCGCGGCGGGCCTGGCGATCGCCACGGCCGACGGCTATAT
CGCCGCCATTGCCGCCGCCAACGGGTTTTCCGTGGCCACGCGCGACGCGAGCCCGTTCGAGGCTGCCGGAGTCGCCGTCA
TCAACCCGTGGGCGGCATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9328.66 Da        Isoelectric Point: 7.2069

>AT81268 WP_096446282.1 NZ_CP023439:1238260-1238514 [Thauera sp. K11]
MAMLTVRNLPDEVHRALRVRAAMHGRSTEAEVREILESAVKPEGRVKLGSLLADIGRRAGLTDEEFAVFEQARDKTPARP
ASFE

Download         Length: 255 bp

>AT81268 NZ_CP023439:1238260-1238514 [Thauera sp. K11]
TTGGCCATGCTGACAGTGCGCAATCTGCCCGACGAGGTGCATCGCGCCCTGCGCGTGCGAGCCGCCATGCACGGCCGCAG
CACGGAAGCGGAGGTGCGCGAGATTCTGGAATCGGCCGTGAAGCCGGAAGGGCGGGTGAAGCTGGGCTCCCTGCTGGCCG
ACATCGGCCGCCGGGCCGGGCTGACCGATGAAGAGTTCGCCGTCTTCGAGCAGGCGCGTGACAAGACCCCGGCCCGGCCG
GCGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References