Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1158591..1159261 Replicon chromosome
Accession NZ_CP023439
Organism Thauera sp. K11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CCZ27_RS05080 Protein ID WP_096446138.1
Coordinates 1158591..1159034 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CCZ27_RS05085 Protein ID WP_096446140.1
Coordinates 1159031..1159261 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ27_RS05055 1153701..1154441 + 741 WP_096446130.1 flagellar motor protein -
CCZ27_RS05060 1154481..1155365 + 885 WP_096446132.1 flagellar motor protein MotD -
CCZ27_RS05065 1155438..1157852 - 2415 WP_096446134.1 DNA topoisomerase IV subunit A -
CCZ27_RS05075 1158137..1158442 + 306 WP_096446136.1 HigA family addiction module antidote protein -
CCZ27_RS05080 1158591..1159034 - 444 WP_096446138.1 type II toxin-antitoxin system VapC family toxin Toxin
CCZ27_RS05085 1159031..1159261 - 231 WP_096446140.1 antitoxin Antitoxin
CCZ27_RS05090 1159320..1161293 - 1974 WP_096446142.1 type IIA DNA topoisomerase subunit B -
CCZ27_RS05095 1161358..1161849 - 492 WP_096446144.1 flagellar protein FlgN -
CCZ27_RS05100 1161893..1162201 - 309 WP_096446146.1 flagellar biosynthesis anti-sigma factor FlgM -
CCZ27_RS05105 1162522..1163273 - 752 Protein_998 flagellar basal body P-ring formation protein FlgA -
CCZ27_RS05110 1163496..1163900 + 405 WP_096446148.1 flagellar basal body rod protein FlgB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16225.71 Da        Isoelectric Point: 5.7501

>T81267 WP_096446138.1 NZ_CP023439:c1159034-1158591 [Thauera sp. K11]
VRYMLDTNICIYLINHRPPQVRRRFDACAVGEVGISIVTATELAYGVAKSGSVRNRAALETFLLPLEIAPLDERVLWRYA
DLRADLERRGQPIGALDTQIAAHALALGATLVTNDTREFQRVAGLMLENWIEPLLSEPPAPYLAATG

Download         Length: 444 bp

>T81267 NZ_CP023439:c1159034-1158591 [Thauera sp. K11]
GTGAGGTACATGCTCGACACCAACATCTGCATCTACCTCATCAACCACCGTCCGCCCCAGGTGCGCCGGCGTTTCGATGC
CTGTGCCGTCGGCGAGGTCGGCATCTCCATCGTCACCGCCACCGAACTGGCCTACGGCGTCGCCAAGAGCGGATCGGTGC
GCAACCGCGCGGCGCTGGAAACCTTTCTGCTGCCGCTGGAGATCGCCCCCCTGGACGAACGGGTGCTGTGGCGCTACGCC
GACCTGCGTGCCGACCTGGAACGGCGCGGCCAGCCCATCGGCGCGCTCGACACCCAGATCGCCGCCCACGCCCTGGCACT
GGGCGCCACACTGGTCACAAACGATACGCGCGAGTTCCAGCGCGTCGCCGGCCTGATGCTGGAGAACTGGATCGAACCGC
TGCTCTCCGAACCACCGGCACCCTACCTCGCGGCAACCGGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8710.96 Da        Isoelectric Point: 5.0931

>AT81267 WP_096446140.1 NZ_CP023439:c1159261-1159031 [Thauera sp. K11]
VETAKLFINGRSQAVRLPKEYRFDGEEVFIKRVGDAVVLLPRHGWNTLFQGLEAFEPGFVMEREQPPQDAREALLP

Download         Length: 231 bp

>AT81267 NZ_CP023439:c1159261-1159031 [Thauera sp. K11]
GTGGAAACCGCCAAGCTCTTCATCAACGGCCGCAGCCAGGCCGTCCGGCTGCCCAAGGAGTACCGCTTCGACGGCGAGGA
AGTCTTCATCAAGCGCGTCGGCGACGCCGTGGTGCTGCTGCCGCGCCACGGCTGGAATACGCTGTTCCAGGGTCTGGAAG
CATTCGAGCCGGGCTTCGTCATGGAACGCGAACAGCCGCCCCAGGACGCGCGCGAGGCACTGCTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References