Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3512..4034 Replicon plasmid pFORC74_3
Accession NZ_CP023438
Organism Salmonella enterica strain FORC_074

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag FORC74_RS24415 Protein ID WP_000220561.1
Coordinates 3512..3793 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FORC74_RS24420 Protein ID WP_000121743.1
Coordinates 3783..4034 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC74_RS24365 34..108 - 75 Protein_1 DNA distortion polypeptide 3 -
FORC74_RS24375 365..637 - 273 WP_000167280.1 hypothetical protein -
FORC74_RS24380 654..800 - 147 WP_001567307.1 hypothetical protein -
FORC74_RS24385 870..1049 - 180 WP_000439079.1 hypothetical protein -
FORC74_RS24390 1092..1421 - 330 WP_000866654.1 hypothetical protein -
FORC74_RS24395 1515..1757 - 243 WP_000008708.1 hypothetical protein -
FORC74_RS24400 1747..1959 - 213 WP_001446884.1 hypothetical protein -
FORC74_RS24405 2025..2573 - 549 WP_001178641.1 hypothetical protein -
FORC74_RS24410 2647..3162 - 516 WP_001025387.1 J domain-containing protein -
FORC74_RS24415 3512..3793 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC74_RS24420 3783..4034 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FORC74_RS24425 5099..5968 + 870 WP_001212191.1 replication initiation protein -
FORC74_RS24430 5973..6824 + 852 WP_000435059.1 replication initiation protein -
FORC74_RS24435 6828..7274 + 447 WP_001074378.1 hypothetical protein -
FORC74_RS24440 7342..7764 + 423 WP_000202950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..51931 51931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T81266 WP_000220561.1 NZ_CP023438:c3793-3512 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T81266 NZ_CP023438:c3793-3512 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>AT81266 WP_000121743.1 NZ_CP023438:c4034-3783 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>AT81266 NZ_CP023438:c4034-3783 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References