Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 55258..55783 Replicon plasmid pFORC74_2
Accession NZ_CP023437
Organism Salmonella enterica strain FORC_074

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag FORC74_RS24320 Protein ID WP_001159863.1
Coordinates 55258..55563 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag FORC74_RS24325 Protein ID WP_000813641.1
Coordinates 55565..55783 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC74_RS24280 50639..51199 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
FORC74_RS24285 51355..51642 + 288 WP_071530243.1 hypothetical protein -
FORC74_RS24290 51919..52404 - 486 WP_000905606.1 membrane protein -
FORC74_RS24295 52398..52907 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
FORC74_RS24300 52911..53624 - 714 WP_000545756.1 EAL domain-containing protein -
FORC74_RS24305 53633..54415 - 783 WP_000082169.1 site-specific integrase -
FORC74_RS24310 54450..54970 - 521 Protein_72 cytoplasmic protein -
FORC74_RS24315 54967..55256 - 290 Protein_73 cytoplasmic protein -
FORC74_RS24320 55258..55563 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
FORC74_RS24325 55565..55783 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FORC74_RS24330 56540..56980 + 441 WP_118892833.1 hypothetical protein -
FORC74_RS24940 57024..57452 - 429 Protein_77 hypothetical protein -
FORC74_RS24340 57464..57759 + 296 Protein_78 cytoplasmic protein -
FORC74_RS24345 58253..59242 + 990 WP_000461382.1 RepB family plasmid replication initiator protein -
FORC74_RS24350 59569..59730 - 162 WP_015059604.1 hypothetical protein -
FORC74_RS24355 59783..60169 - 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60923 60923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T81265 WP_001159863.1 NZ_CP023437:c55563-55258 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T81265 NZ_CP023437:c55563-55258 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT81265 WP_000813641.1 NZ_CP023437:c55783-55565 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT81265 NZ_CP023437:c55783-55565 [Salmonella enterica]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References