Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 4325912..4326438 Replicon chromosome
Accession NZ_CP023435
Organism Mycobacterium sp. PYR15

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag CAC50_RS21180 Protein ID WP_071942669.1
Coordinates 4325912..4326214 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag CAC50_RS21185 Protein ID WP_096312006.1
Coordinates 4326211..4326438 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAC50_RS21165 4320953..4324450 + 3498 WP_071949672.1 indolepyruvate ferredoxin oxidoreductase family protein -
CAC50_RS21170 4324708..4324941 + 234 Protein_4180 hypothetical protein -
CAC50_RS21175 4325166..4325852 - 687 WP_071942671.1 hypothetical protein -
CAC50_RS21180 4325912..4326214 - 303 WP_071942669.1 toxin Toxin
CAC50_RS21185 4326211..4326438 - 228 WP_096312006.1 ribbon-helix-helix protein, CopG family Antitoxin
CAC50_RS30300 4326925..4328220 + 1296 WP_174714139.1 helix-turn-helix domain-containing protein -
CAC50_RS21195 4328815..4329807 + 993 WP_096312963.1 hypothetical protein -
CAC50_RS21200 4329800..4330288 + 489 WP_096312007.1 DNA-binding protein -
CAC50_RS21205 4330300..4330578 - 279 WP_096312964.1 hypothetical protein -
CAC50_RS21210 4330718..4331023 + 306 WP_096312965.1 hypothetical protein -
CAC50_RS21215 4331020..4331331 + 312 WP_096312008.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10398.96 Da        Isoelectric Point: 4.1775

>T81263 WP_071942669.1 NZ_CP023435:c4326214-4325912 [Mycobacterium sp. PYR15]
VIAPGDIAPRRDTSHEVYVVVLSNSIHLAADTGRVITCPFIPGEIPDAAMALVVRVEHPEGVALPELVQWLPVAALDEPI
GNIGTNALGDTASLVTALVT

Download         Length: 303 bp

>T81263 NZ_CP023435:c4326214-4325912 [Mycobacterium sp. PYR15]
GTGATCGCTCCCGGTGACATCGCGCCACGTCGCGATACCAGCCATGAGGTCTATGTTGTCGTGCTGTCTAACTCGATTCA
CCTGGCAGCCGATACCGGCCGAGTCATTACCTGCCCTTTTATTCCAGGCGAAATCCCCGACGCTGCAATGGCGTTGGTCG
TTCGAGTCGAACACCCCGAAGGCGTGGCGCTACCCGAGCTTGTTCAGTGGCTTCCCGTAGCAGCACTGGACGAGCCGATC
GGCAACATCGGGACGAACGCGCTAGGTGACACAGCGTCTCTCGTAACAGCCCTCGTCACCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8198.26 Da        Isoelectric Point: 7.1999

>AT81263 WP_096312006.1 NZ_CP023435:c4326438-4326211 [Mycobacterium sp. PYR15]
MAKDKVSITLDQDVLAKADADAKAAGLNRSELVEQALRHEHLRIALKSYTSTTVPALSIDDYAQRIYQANRASGL

Download         Length: 228 bp

>AT81263 NZ_CP023435:c4326438-4326211 [Mycobacterium sp. PYR15]
ATGGCGAAAGACAAGGTGTCGATCACACTCGATCAGGACGTGCTGGCAAAGGCCGATGCCGACGCCAAAGCCGCTGGGCT
CAACCGGTCCGAATTGGTTGAGCAGGCTTTGCGCCACGAGCACCTTCGGATCGCGCTCAAGAGCTACACATCGACGACCG
TCCCCGCGCTGAGCATCGACGATTACGCGCAGAGGATCTACCAGGCGAATCGGGCCTCGGGTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References