Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2772625..2773295 Replicon chromosome
Accession NZ_CP023435
Organism Mycobacterium sp. PYR15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CAC50_RS13615 Protein ID WP_096311397.1
Coordinates 2772625..2773023 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CAC50_RS13620 Protein ID WP_096311398.1
Coordinates 2773020..2773295 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CAC50_RS13595 2769143..2769508 + 366 WP_071945079.1 nitrite reductase small subunit NirD -
CAC50_RS13600 2769480..2770625 + 1146 WP_071945077.1 uroporphyrinogen-III synthase -
CAC50_RS13605 2770622..2771299 + 678 WP_096311395.1 sirohydrochlorin chelatase -
CAC50_RS13610 2771329..2772621 + 1293 WP_096311396.1 threonine ammonia-lyase IlvA -
CAC50_RS13615 2772625..2773023 - 399 WP_096311397.1 type II toxin-antitoxin system VapC family toxin Toxin
CAC50_RS13620 2773020..2773295 - 276 WP_096311398.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CAC50_RS13630 2773774..2774607 - 834 WP_096311400.1 helix-turn-helix transcriptional regulator -
CAC50_RS13635 2774735..2775583 + 849 WP_096311401.1 SDR family NAD(P)-dependent oxidoreductase -
CAC50_RS13640 2775580..2777304 - 1725 WP_096311402.1 malto-oligosyltrehalose trehalohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14360.67 Da        Isoelectric Point: 7.2013

>T81262 WP_096311397.1 NZ_CP023435:c2773023-2772625 [Mycobacterium sp. PYR15]
MMQVYLDTSALMKLVVLEPETPALRTYLTQYPDDVRFTAALSRTELLRAVRRSGSYELAAQAHRLLGRLDLVAMTTRLLD
EAGTIGPPELRTLDAIHLAAARTAPALRSLVTYDLRLAAAAEAVGVTVATPQ

Download         Length: 399 bp

>T81262 NZ_CP023435:c2773023-2772625 [Mycobacterium sp. PYR15]
TTGATGCAGGTTTACCTCGACACCTCCGCTTTGATGAAACTCGTGGTCCTCGAGCCCGAAACACCAGCACTACGAACGTA
TTTGACACAGTATCCCGACGATGTCCGGTTCACCGCGGCACTGTCGCGTACCGAGCTGCTCAGGGCAGTCCGGCGCAGCG
GCTCGTATGAGCTTGCCGCACAAGCTCACCGACTGCTGGGCCGACTCGACTTGGTTGCAATGACTACCCGGCTGCTCGAC
GAAGCCGGCACAATCGGACCGCCCGAGCTGAGGACGCTGGACGCGATCCACTTGGCGGCCGCGCGTACCGCGCCTGCGTT
GCGGAGCCTTGTCACATACGACCTCCGGCTTGCCGCGGCCGCCGAGGCCGTAGGCGTCACAGTCGCGACCCCGCAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10323.69 Da        Isoelectric Point: 5.1677

>AT81262 WP_096311398.1 NZ_CP023435:c2773295-2773020 [Mycobacterium sp. PYR15]
MCYMERIGLRELRQHASQYVDRAAGGESIEITVRGRLVAMLVPAGEGTWDDLIVRGEVLPAPSRLNLLDEPARDYGFDAS
ESLRRLRDHER

Download         Length: 276 bp

>AT81262 NZ_CP023435:c2773295-2773020 [Mycobacterium sp. PYR15]
ATGTGCTACATGGAGCGCATCGGGCTGCGAGAGCTGCGCCAGCATGCGAGCCAGTATGTCGACCGAGCAGCCGGCGGCGA
ATCCATCGAAATCACCGTGCGTGGGCGACTGGTAGCCATGCTGGTGCCCGCTGGTGAGGGAACCTGGGACGACCTGATTG
TGCGCGGCGAGGTGCTACCGGCTCCGTCGCGCCTGAATCTGCTCGACGAACCGGCGCGGGACTACGGTTTCGACGCATCA
GAATCCTTGCGTCGACTTCGGGACCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References