Detailed information of TA system TA081261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 907378..908036
• Replicon: chromosome
• Accession: NZ_CP023435
• Organism: Mycobacterium sp. PYR15

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CAC50_RS04275
• Protein ID: WP_096309973.1
• Coordinates: 907638..908036 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CAC50_RS04270
• Protein ID: WP_096309971.1
• Coordinates: 907378..907641 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CAC50_RS04230	902509..903759	+	1251	WP_096309961.1	cytochrome P450	-
CAC50_RS04235	903823..904248	+	426	WP_096309963.1	hypothetical protein	-
CAC50_RS04240	904333..904728	-	396	WP_096309965.1	type II toxin-antitoxin system VapC family toxin	-
CAC50_RS04245	904729..904977	-	249	WP_071947610.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CAC50_RS04250	905110..905307	+	198	WP_096312685.1	antitoxin Phd	-
CAC50_RS04255	905304..905687	+	384	WP_071947609.1	type II toxin-antitoxin system death-on-curing family toxin	-
CAC50_RS04260	905767..906345	+	579	WP_096309967.1	hypothetical protein	-
CAC50_RS04265	906404..907315	+	912	WP_096309969.1	hypothetical protein	-
CAC50_RS04270	907378..907641	+	264	WP_096309971.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CAC50_RS04275	907638..908036	+	399	WP_096309973.1	type II toxin-antitoxin system VapC family toxin	Toxin
CAC50_RS04280	908078..909736	+	1659	WP_125477387.1	hypothetical protein	-
CAC50_RS04285	909747..910229	-	483	WP_164520017.1	hypothetical protein	-
CAC50_RS04290	910345..911151	+	807	WP_096312687.1	glycoside hydrolase family 16 protein	-
CAC50_RS04295	911155..911367	+	213	WP_096309977.1	hypothetical protein	-
CAC50_RS04300	911443..912669	-	1227	WP_096309979.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	895551..909736	14185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-86)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14036.00 Da
• Isoelectric Point: 4.8998

>T81261 WP_096309973.1 NZ_CP023435:907638-908036 [Mycobacterium sp. PYR15]
VIVDTSAIVAIALNESGRDRLVDALVGAAEPKISAATLVEVAAVLMRRLKPEDLRRVERLIDQLGIVRVSFDAEQAASVT
RAYREFGRGSGHRAGLNLGDCYSYALAAVTGEPLLFVGDDFTHTDITPAALG

Nucleotide

• Length: 399 bp

>T81261 NZ_CP023435:907638-908036 [Mycobacterium sp. PYR15]
GTGATCGTCGATACGTCGGCGATCGTGGCCATAGCGCTCAACGAGTCGGGGCGTGATCGGTTAGTCGACGCGCTGGTGGG
CGCAGCCGAGCCGAAGATCTCCGCGGCCACGCTGGTCGAGGTGGCGGCGGTCCTCATGAGGCGACTGAAACCCGAAGACT
TACGACGCGTGGAGCGCCTCATCGACCAATTAGGCATCGTGAGAGTGTCTTTCGATGCCGAGCAGGCTGCGAGTGTCACA
CGCGCCTACCGTGAGTTCGGACGTGGCAGCGGCCATCGCGCGGGCCTGAATCTTGGTGACTGCTACTCCTACGCCCTTGC
CGCGGTCACCGGTGAACCATTGCTGTTCGTCGGCGACGACTTCACCCATACGGATATCACTCCGGCCGCTCTCGGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9649.82 Da
• Isoelectric Point: 6.3472

>AT81261 WP_096309971.1 NZ_CP023435:907378-907641 [Mycobacterium sp. PYR15]
MSLNIKNPQTVALVRELARRTGLSQTSAVEEAVRAKLAQLTADEGGDTRRQKVNDLLAELDRSITAQQRKSIRKDETDLY
DENGLPA

Nucleotide

• Length: 264 bp

>AT81261 NZ_CP023435:907378-907641 [Mycobacterium sp. PYR15]
ATGAGTCTGAACATCAAGAACCCGCAGACGGTTGCGCTGGTCCGGGAGCTCGCGCGGCGTACGGGACTCAGTCAGACGAG
CGCCGTCGAAGAAGCGGTGCGTGCCAAGCTTGCCCAGCTCACCGCCGATGAGGGTGGGGATACTCGACGCCAGAAGGTCA
ACGACTTGCTCGCCGAACTGGATCGGTCGATCACCGCGCAGCAGCGCAAGTCCATTCGTAAAGACGAGACCGACTTGTAT
GACGAGAACGGGTTGCCTGCGTGA