Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1083640..1084271 Replicon chromosome
Accession NZ_CP023429
Organism Neisseria sp. 10022

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CGZ65_RS05580 Protein ID WP_198345378.1
Coordinates 1083640..1084029 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CGZ65_RS05585 Protein ID WP_096295144.1
Coordinates 1084041..1084271 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGZ65_RS05555 1079602..1081176 + 1575 WP_096295138.1 conjugal transfer protein TraN -
CGZ65_RS12790 1081166..1081654 + 489 WP_157742716.1 hypothetical protein -
CGZ65_RS05565 1081569..1082363 + 795 WP_096295140.1 conjugal transfer protein TraF -
CGZ65_RS05570 1082400..1082660 + 261 WP_096295141.1 hypothetical protein -
CGZ65_RS05575 1082809..1083630 - 822 WP_096295142.1 hypothetical protein -
CGZ65_RS05580 1083640..1084029 - 390 WP_198345378.1 type II toxin-antitoxin system VapC family toxin Toxin
CGZ65_RS05585 1084041..1084271 - 231 WP_096295144.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CGZ65_RS05590 1084404..1085555 + 1152 WP_096295145.1 ATP-binding protein -
CGZ65_RS05595 1085611..1086357 + 747 WP_096295146.1 hypothetical protein -
CGZ65_RS05600 1086362..1087327 + 966 WP_096295147.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1065527..1145837 80310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(7-31)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.97 Da        Isoelectric Point: 6.2211

>T81256 WP_198345378.1 NZ_CP023429:c1084029-1083640 [Neisseria sp. 10022]
MLDTNICIYIINQKPKYVFEKFEQYTPGEIAISSITACELAFGVEKSNSSKNKDALMKFLTPLDILPFDDSVIWHYARVR
QHLQSKGMPIGSLDLLIAAHALSLGIPLVSNNTKEFERVDGLYLENWIK

Download         Length: 390 bp

>T81256 NZ_CP023429:c1084029-1083640 [Neisseria sp. 10022]
CTGTTGGATACCAATATCTGCATTTACATTATTAATCAGAAACCGAAATATGTATTTGAAAAGTTTGAACAATATACTCC
GGGTGAGATCGCCATATCCAGCATTACGGCCTGCGAATTGGCATTTGGCGTAGAAAAATCAAATTCTTCCAAAAACAAAG
ATGCTTTAATGAAGTTCTTAACCCCTTTGGATATTCTGCCTTTTGACGATTCTGTTATCTGGCATTATGCCCGTGTTCGC
CAACATTTACAAAGCAAGGGTATGCCTATCGGCAGTCTTGACCTTTTAATTGCAGCTCACGCCTTGTCTTTAGGCATCCC
ACTGGTCAGCAATAACACCAAGGAATTTGAACGCGTAGACGGTCTGTATTTGGAAAACTGGATTAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8918.25 Da        Isoelectric Point: 4.8353

>AT81256 WP_096295144.1 NZ_CP023429:c1084271-1084041 [Neisseria sp. 10022]
MQTAKIFINGRSQAVRLPKEFRFEEKEVFIKHFAGGVLLIPKENSWQNMAQAVEEFEPGFVLEREPQVEQIRDEIL

Download         Length: 231 bp

>AT81256 NZ_CP023429:c1084271-1084041 [Neisseria sp. 10022]
ATGCAAACAGCTAAAATATTTATCAACGGCCGTTCACAGGCAGTTCGACTGCCTAAAGAGTTTAGATTTGAAGAAAAAGA
GGTCTTTATCAAACACTTTGCCGGCGGCGTATTACTGATTCCAAAGGAAAACAGTTGGCAGAACATGGCTCAAGCAGTTG
AAGAATTTGAACCCGGTTTCGTATTGGAGCGCGAACCGCAGGTTGAGCAAATCCGGGACGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References