Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 706275..706843 Replicon chromosome
Accession NZ_CP023429
Organism Neisseria sp. 10022

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CGZ65_RS03545 Protein ID WP_096294847.1
Coordinates 706275..706568 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CGZ65_RS03550 Protein ID WP_096294848.1
Coordinates 706556..706843 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGZ65_RS03500 701624..702244 + 621 WP_089036151.1 recombinase family protein -
CGZ65_RS03505 702245..702454 + 210 WP_096294840.1 hypothetical protein -
CGZ65_RS03510 702461..702916 + 456 WP_096294841.1 Fic family protein -
CGZ65_RS03515 702913..703410 + 498 WP_096294842.1 hypothetical protein -
CGZ65_RS03525 703695..704240 - 546 WP_096296083.1 hypothetical protein -
CGZ65_RS03530 704230..704691 - 462 WP_096294844.1 hypothetical protein -
CGZ65_RS03535 704757..705155 - 399 WP_096294845.1 phosphoglycerate kinase -
CGZ65_RS03540 705951..706247 + 297 WP_157742691.1 hypothetical protein -
CGZ65_RS03545 706275..706568 - 294 WP_096294847.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGZ65_RS03550 706556..706843 - 288 WP_096294848.1 ribbon-helix-helix domain-containing protein Antitoxin
CGZ65_RS03555 707024..707366 - 343 Protein_691 endoribonuclease MazF -
CGZ65_RS03560 707363..707602 - 240 WP_096294849.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CGZ65_RS03565 708109..708303 + 195 WP_157742692.1 hypothetical protein -
CGZ65_RS03570 708300..708512 + 213 WP_096294851.1 hypothetical protein -
CGZ65_RS03575 708609..708854 + 246 WP_096294852.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CGZ65_RS03580 708851..709236 + 386 Protein_696 type II toxin-antitoxin system VapC family toxin -
CGZ65_RS03585 709297..709584 - 288 WP_096294853.1 type II toxin-antitoxin system RelE/ParE family toxin -
CGZ65_RS03590 709581..709847 - 267 WP_096294854.1 hypothetical protein -
CGZ65_RS03595 710369..711157 - 789 WP_096294855.1 hypothetical protein -
CGZ65_RS03600 711169..711381 - 213 WP_096294856.1 helix-turn-helix domain-containing protein -
CGZ65_RS03605 711501..711806 + 306 WP_096294857.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 676141..721558 45417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10873.36 Da        Isoelectric Point: 5.0622

>T81255 WP_096294847.1 NZ_CP023429:c706568-706275 [Neisseria sp. 10022]
MPQVMLTEHATADLRRLYDFLALKNEQAARNAVKAVRDALAGLAQFPAAGRFFDDEYREWPVSFGDAGYTILYRIDPETV
VIVAIKHQSGIELQFSG

Download         Length: 294 bp

>T81255 NZ_CP023429:c706568-706275 [Neisseria sp. 10022]
ATGCCACAAGTAATGTTAACCGAACATGCGACGGCTGATTTACGACGGCTCTACGATTTTTTAGCACTGAAAAACGAACA
AGCTGCACGAAATGCGGTAAAAGCCGTTAGGGACGCTTTGGCAGGTTTGGCACAATTTCCTGCCGCCGGCCGTTTTTTTG
ATGATGAATACCGGGAATGGCCGGTTTCCTTCGGAGATGCAGGTTATACCATTTTATATCGGATTGATCCTGAAACCGTT
GTGATTGTGGCGATTAAGCACCAATCGGGAATTGAGTTACAGTTTTCCGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10802.41 Da        Isoelectric Point: 6.8725

>AT81255 WP_096294848.1 NZ_CP023429:c706843-706556 [Neisseria sp. 10022]
MKPKTVPVAVKLPLEIRDRLKAVAETQDRSVHWLMREAVNQFLEREEQKAALRAAADASWAHYQETGLHVTLEEANVWMG
AIIEGREAGELKCHK

Download         Length: 288 bp

>AT81255 NZ_CP023429:c706843-706556 [Neisseria sp. 10022]
ATGAAACCGAAAACCGTGCCTGTGGCCGTCAAATTACCGCTGGAAATCAGAGACCGTTTGAAAGCAGTTGCCGAAACCCA
AGATCGCTCTGTGCATTGGTTGATGCGGGAAGCGGTCAACCAATTTTTGGAACGTGAGGAGCAGAAAGCTGCTTTACGTG
CCGCAGCCGATGCTTCTTGGGCCCACTATCAAGAAACCGGCCTGCATGTTACGTTGGAAGAGGCGAATGTATGGATGGGT
GCAATTATTGAGGGAAGAGAAGCCGGGGAATTGAAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References