Detailed information of TA system TA081247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/StbC(antitoxin)
• Location: 1301629..1302258
• Replicon: chromosome
• Accession: NZ_CP023422
• Organism: Janthinobacterium svalbardensis strain PAMC 27463

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CNX70_RS05775
• Protein ID: WP_096233918.1
• Coordinates: 1301842..1302258 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CNX70_RS05770
• Protein ID: WP_096233917.1
• Coordinates: 1301629..1301838 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNX70_RS05745	1297314..1297493	-	180	WP_096233912.1	hypothetical protein	-
CNX70_RS05750	1297460..1298602	-	1143	WP_157750910.1	alpha/beta hydrolase	-
CNX70_RS05755	1298848..1300086	+	1239	WP_096233914.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-
CNX70_RS05760	1300083..1300964	+	882	WP_096233915.1	ATP-binding protein	-
CNX70_RS05765	1300961..1301383	+	423	WP_096233916.1	NUDIX domain-containing protein	-
CNX70_RS05770	1301629..1301838	+	210	WP_096233917.1	DNA-binding protein	Antitoxin
CNX70_RS05775	1301842..1302258	+	417	WP_096233918.1	type II toxin-antitoxin system VapC family toxin	Toxin
CNX70_RS05780	1302272..1302463	-	192	WP_034748814.1	DNA gyrase inhibitor YacG	-
CNX70_RS05785	1302482..1303237	-	756	WP_071079369.1	cell division protein ZapD	-
CNX70_RS05790	1303321..1303947	-	627	WP_096233919.1	dephospho-CoA kinase	-
CNX70_RS05795	1303981..1304849	-	869	Protein_1128	prepilin peptidase	-
CNX70_RS05800	1305015..1305536	-	522	WP_157750911.1	DUF2867 domain-containing protein	-
CNX70_RS05805	1305646..1306296	-	651	WP_096233921.1	DJ-1/PfpI family protein	-
CNX70_RS05810	1306420..1306809	-	390	WP_096233922.1	hypothetical protein	-
CNX70_RS28500	1306790..1306978	-	189	WP_167389616.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14751.09 Da
• Isoelectric Point: 5.1468

>T81247 WP_096233918.1 NZ_CP023422:1301842-1302258 [Janthinobacterium svalbardensis]
MAAYLVDTDVIVAARKGGAAPPGVLAFFERVAPEACYVPVQVIAQLRAGIQRSWRREAALEALALEGWLEAVLAEYAPRL
LEFDLDCALVCARLHGRGLAHGVDGQIAAMGIAYGLTVVSGRLDSFVTQGLRLENPFS

Nucleotide

• Length: 417 bp

>T81247 NZ_CP023422:1301842-1302258 [Janthinobacterium svalbardensis]
ATGGCCGCCTACCTGGTCGATACGGATGTGATCGTTGCGGCGCGCAAGGGCGGCGCGGCACCGCCAGGCGTGCTCGCCTT
TTTCGAACGGGTAGCGCCTGAAGCGTGCTATGTGCCGGTGCAGGTGATTGCGCAGTTGCGTGCAGGCATACAGCGCAGCT
GGCGGCGCGAAGCGGCGCTGGAAGCACTGGCGCTGGAAGGCTGGCTGGAAGCCGTGCTGGCAGAGTATGCGCCGCGGCTG
CTGGAATTCGACCTTGATTGCGCACTCGTGTGCGCGCGCCTGCATGGCCGGGGCCTCGCGCACGGCGTCGATGGACAGAT
CGCGGCGATGGGCATCGCCTATGGCTTGACGGTGGTCAGCGGCAGGCTCGACAGTTTCGTGACGCAGGGACTGCGCCTGG
AAAATCCGTTTAGTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7959.15 Da
• Isoelectric Point: 5.6773

>AT81247 WP_096233917.1 NZ_CP023422:1301629-1301838 [Janthinobacterium svalbardensis]
MPLTLTFTDTDELLIAALYKRARAHGRSIEEEHRDILRSALRPLPKRPLEDILRSMPDVGVDTDFECRP

Nucleotide

• Length: 210 bp

>AT81247 NZ_CP023422:1301629-1301838 [Janthinobacterium svalbardensis]
ATGCCGCTGACACTGACCTTTACCGATACCGATGAATTGCTGATCGCCGCGCTGTACAAGCGTGCCCGCGCGCATGGGCG
CAGCATCGAAGAGGAGCACCGCGACATCCTGCGCAGCGCCTTGCGACCGCTGCCGAAGCGTCCGCTCGAGGATATTTTGC
GCAGCATGCCCGACGTGGGGGTCGACACGGATTTCGAGTGCCGCCCTTGA