Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2736019..2736550 Replicon chromosome
Accession NZ_CP023415
Organism Desulfovibrio sp. G11

Toxin (Protein)


Gene name relE Uniprot ID A0A807ZN29
Locus tag CNY67_RS12380 Protein ID WP_072311502.1
Coordinates 2736019..2736315 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A807ZMD3
Locus tag CNY67_RS12385 Protein ID WP_072311503.1
Coordinates 2736305..2736550 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNY67_RS12355 2731250..2732845 - 1596 WP_072311497.1 VWA domain-containing protein -
CNY67_RS12360 2732981..2733217 - 237 WP_072311498.1 hypothetical protein -
CNY67_RS12365 2733277..2734314 - 1038 WP_072311499.1 DUF3150 domain-containing protein -
CNY67_RS12370 2734324..2735658 - 1335 WP_072311500.1 AAA family ATPase -
CNY67_RS12375 2735758..2735958 - 201 WP_072311501.1 hypothetical protein -
CNY67_RS12380 2736019..2736315 - 297 WP_072311502.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNY67_RS12385 2736305..2736550 - 246 WP_072311503.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CNY67_RS12390 2736618..2736866 - 249 WP_083577880.1 hypothetical protein -
CNY67_RS12395 2736994..2737536 - 543 WP_072311504.1 hypothetical protein -
CNY67_RS12400 2737650..2738267 + 618 WP_187008400.1 DUF3696 domain-containing protein -
CNY67_RS15785 2738264..2739217 + 954 WP_143142576.1 hypothetical protein -
CNY67_RS12410 2739232..2740095 + 864 WP_096152720.1 restriction endonuclease -
CNY67_RS12415 2740207..2740479 + 273 WP_072311507.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CNY67_RS12420 2740460..2740720 + 261 WP_072311508.1 Txe/YoeB family addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2712808..2749295 36487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-68)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11693.67 Da        Isoelectric Point: 10.5427

>T81225 WP_072311502.1 NZ_CP023415:c2736315-2736019 [Desulfovibrio sp. G11]
MSYSLQFHELALKEWKRLDSSIREQFKKKLAERLQQPRVPSSALSGMRDCYKIKLRSIGYRLVYKVNDDILFVTVISIGK
RERLEAYRQALRRMPSEE

Download         Length: 297 bp

>T81225 NZ_CP023415:c2736315-2736019 [Desulfovibrio sp. G11]
ATGAGCTATAGCCTGCAGTTTCATGAGCTAGCACTGAAAGAATGGAAAAGGCTTGATTCCAGCATCAGAGAACAGTTTAA
AAAGAAACTGGCAGAACGGTTACAACAGCCGAGAGTTCCCTCATCTGCCCTGTCTGGCATGCGCGATTGCTACAAAATCA
AATTGCGCTCCATTGGGTATCGCCTGGTGTACAAGGTGAATGATGACATTCTCTTTGTAACGGTCATCTCCATTGGCAAG
CGTGAACGCCTTGAGGCATATCGACAAGCCCTACGACGTATGCCCTCTGAAGAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9092.42 Da        Isoelectric Point: 4.6388

>AT81225 WP_072311503.1 NZ_CP023415:c2736550-2736305 [Desulfovibrio sp. G11]
MDSILSNITVSVTELKRNFANVLATAKDAPVAVLNHNKPEAYLLSAKHYEEILGILEDLEDRKIVEKREDGPFVKVTLDE
L

Download         Length: 246 bp

>AT81225 NZ_CP023415:c2736550-2736305 [Desulfovibrio sp. G11]
ATGGATTCCATACTCTCCAATATCACCGTTAGCGTCACAGAACTCAAACGGAACTTTGCGAATGTCCTGGCAACTGCCAA
GGATGCGCCGGTGGCAGTTTTGAACCATAACAAGCCAGAGGCCTACCTGTTGTCCGCAAAGCACTACGAAGAAATCCTCG
GAATTCTTGAAGATCTTGAAGACAGAAAGATTGTTGAAAAACGCGAAGATGGCCCTTTTGTCAAGGTAACGCTTGATGAG
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZN29

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZMD3

References