Detailed information of TA system TA081206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4033509..4034137
• Replicon: chromosome
• Accession: NZ_CP023407
• Organism: Streptomyces fungicidicus strain TXX3120

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CNQ36_RS18415
• Protein ID: WP_121546814.1
• Coordinates: 4033727..4034137 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D9XL36
• Locus tag: CNQ36_RS18410
• Protein ID: WP_004928730.1
• Coordinates: 4033509..4033730 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ36_RS18380	4029608..4029874	+	267	WP_121546811.1	ribbon-helix-helix domain-containing protein	-
CNQ36_RS18385	4029871..4030314	+	444	WP_121546812.1	PIN domain-containing protein	-
CNQ36_RS18390	4030923..4031751	+	829	Protein_3582	DUF2182 domain-containing protein	-
CNQ36_RS18395	4031838..4032494	-	657	WP_121546813.1	DUF1326 domain-containing protein	-
CNQ36_RS18400	4033032..4033094	+	63	Protein_3584	addiction module toxin RelE	-
CNQ36_RS18410	4033509..4033730	+	222	WP_004928730.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CNQ36_RS18415	4033727..4034137	+	411	WP_121546814.1	PIN domain-containing protein	Toxin
CNQ36_RS18420	4034165..4034447	+	283	Protein_3587	integrase	-
CNQ36_RS18435	4035894..4036427	+	534	WP_121546815.1	hypothetical protein	-
CNQ36_RS18440	4036395..4036796	-	402	WP_007453332.1	hypothetical protein	-
CNQ36_RS18445	4037106..4037696	+	591	WP_033276641.1	hypothetical protein	-
CNQ36_RS18450	4037702..4037983	+	282	WP_033276642.1	hypothetical protein	-
CNQ36_RS18455	4037980..4039020	-	1041	WP_121546816.1	acyl-CoA desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15031.82 Da
• Isoelectric Point: 6.2112

>T81206 WP_121546814.1 NZ_CP023407:4033727-4034137 [Streptomyces fungicidicus]
VIYLLDTSGLVRLLRDPKLQSAWYDAIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAVQ
HRMARAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIARHASDLTEHNVHDIA

Nucleotide

• Length: 411 bp

>T81206 NZ_CP023407:4033727-4034137 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8561.59 Da
• Isoelectric Point: 7.3209

>AT81206 WP_004928730.1 NZ_CP023407:4033509-4033730 [Streptomyces fungicidicus]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALNFYAEQQERAARISRHFERAREWGAVEDAERLHRAEKRNR

Nucleotide

• Length: 222 bp

>AT81206 NZ_CP023407:4033509-4033730 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Structures

Antitoxin

• AlphaFold DB: D9XL36